Other

Dana-Farber-Cancer Institute Inc.

Harvard College

Robert W Finberg

Evelyn A Kurt-Jones

Keith R Solomon

George Rainer Siber

David M Knipe

Marshall S Horwitz

Jeffrey M Bergelson

Wyrta E Heagy

A herpesvirus vaccine comprising a mutated herpesvirus suspended in a pharmaceutically acceptable carrier. The mutated herpesvirus is capable of infecting cells of the mammal to be vaccinated, but incapable of completing a replicative cycle, and it is capable of eliciting a protective immune response in that mammal. The mutated herpesvirus is also capable of treating immunomodulatory or immunoregulatory diseases. The mutation occurs in at least one gene encoding a protein essential for replication of the virus, so that the mutation renders the virus replication defective.

Herpesvirus replication defective mutants

The present invention provides for the use of G protein binding agents for prophylactic and/or therapeutic treatments of septic shock. The present invention provides methods of using agents which bind G protein to treat a subject having or susceptible to septic shock. The present invention further pertains to compositions for treating a subject for septic shock. The composition includes an effective amount of a G protein binding agent and, optionally, an antibiotic and a pharmaceutically acceptable carrier. Other aspects of the invention include packaged agents which bind G proteins for treating septic shock.

Use of agents which bind G proteins for treating septic shock

The present invention provides for the use of G protein binding agents for prophylactic and/or therapeutic treatment of septic shock. The present invention provides methods of using agents which bind G protein to treat a subject having or susceptible to septic shock. The present invention further pertains to compositions for treating a subject for septic shock. The composition includes an effective amount of a G protein binding agent such as mastoparan and, optionally, an antibiotic and a pharmaceutically acceptable carrier. Other aspects of the invention include packaged agents which bind G proteins for treating septic shock.

The invention provides isolated nucleic acid molecules which encode a coxsackievirus and adenovirus receptor protein, CAR. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing CAR nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a CAR gene has been introduced or disrupted. The invention still further provides isolated CAR proteins, fusion proteins, antigenic peptides and anti-CAR antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.

CAR: a novel coxsackievirus and adenovirus receptor

This invention relates primarily to opioid binding proteins specifically, the invention relates to lymphocyte-specific opioid recognition sites and methods and compositions related to them. For example, methods of determining agonists and antagonists of immune cell-specific opioid binding protein are presented.

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Canton, MA, United States of America

Robert W Finberg