Lonza Inc.

Robert Voeffray

David L Kuo

A process for the production of piperazinylpyrimidine derivatives of the formula: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are the same or different and each is a hydrogen atom or a C.sub.1 -C.sub.4 alkyl group, branched or unbranched. These piperazinylpyrimidine derivatives are acid-converted with cyanamide to an amidine salt starting from piperazine or its hydrate and then reacted with a dicarbonyl compound in the presence of a base to the end product.

Process for the production of piperazinylpyrimidine derivatives

Enantiomer-free 2,2,4-trisubstituted 1,3-dioxolanes of the general formula: ##STR1## wherein R.sup.1 and R.sup.2 are either the same and are (a) hydrogen or

Process for production of enantiomerically pure 2,2,4-trisubstituted

Process for the production of optically-active beta-methylcholine from optically active 3-chloro-2-oxy-propyltrimethyl ammonium chloride.

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Basel, Switzerland

Robert Voeffray