Other

Wyeth

Robert Vincent Martinez

Stephen Berasi

John Martin Wozney

Howard Seeherman

Christopher Todd Brown

Valerie Calabro

Michael John Cain

Zong Sean Juo

Ruth E Gimeno

Christine Huard

Douglas Cotter

Janet E Paulsen

Eugene Lee Brown

Z Sean Juo

Dongmei Li

Heather Shih

Ying Sun

The invention relates to novel designer osteogenic proteins having altered affinity for a cognate receptor, nucleic acids encoding the same, and methods of use therefor. More preferably, the novel designer osteogenic proteins are designer BMPs and have altered affinity for a cognate BMP receptor. The designer BMPs demonstrate altered biological characteristics and provide potential useful novel therapeutics.

Designer osteogenic proteins

Osteogenic proteins

A snack bottle with distensible dispensing cap that includes a deformable container portion attachable to a rubberlike dispensing cap, said dispensing cap having a slit opening rendered linearly therein, wherein deformation of the container portion by application of manual pressure thereto distends the slit opening in the dispensing cap, and snacks additional to the container portion are transmissible through the dispensing cap when the slit opening is distended, whereby snacks storable within the container portion are dispensable singlehandedly from said container portion.

Snack bottle with distensible dispensing cap

The present invention provides methods of affecting gluconeogenesis by altering the levels or activity of DUSP4 and/or EGR1. Pharmaceutical compositions comprising or encoding modulators of gluconeogenesis are also disclosed.

Modulators of gluconeogenesis

A paintball gun utilizing the Coanda effect in firing and/or loading paintballs. A Coanda chamber located in the bolt, feed tube, or barrel propels, loads, or spins a paintball. The Coanda chambers, which can be used in any combination include a port for receiving air, an inner cell, an outer cell and an annular ring defining a passageway between the cells. The chamber located in the bolt for propelling the ball includes walls in the outer cell. The air follows the sloped walls and hits the ball at its periphery, eliminating distortion and breakage of the ball. The chamber located in the feed tube forces the ball into the barrel and creates a vacuum to eliminate the ball blowing back up the feed tube. The annular ring in the chamber in the barrel is partially blocked, directing the air to put a spin on the ball.

Paintball gun with Coanda effect

A golf club caddy has a pair of standards, each of the standards having a ground supporting member projecting from a lower end. A plurality of U-shaped engagement members are fixed to opposite faces of each standard for receiving the shaft of a golf club. Spacing members are positioned between the pair of standards with a grip portion being centrally located between the ends of an uppermost spacing member for providing a comfortable grip for carrying the caddy. Releasable coupling members extend into the spacing members from each standard. Each of the coupling members includes a proximal and a distal wedge member received into the ends of the spacing members and having outer surfaces sized to engage an inner surface of the spacing members. A threaded member extends through the wedge members so that the proximal wedge is slidably arranged on the threaded member while the distal wedge member is engaged by the threaded member. A handle is connected to each threaded member so that rotation of the handle member causes displacement of the distal wedge member with respect to the spacing member for manual release of the coupling member whereby the standards and spacing members can be quickly and easily disassembled for storage as well as reassembled subsequent to storage.

Golf club caddy

A merchandise display guard and seal system which uses a generally flat elongated flexible strip having a thickness and a pair of side edges defining a width, the width being substantially larger than the thickness. The strip includes a first fold line which is substantially parallel to one of the side edges and which provides a flexible section for dividing the strip into a sidewall section and a seal section; and a scored section, the scored section being at an angle to the first fold line and extending from one of the side edges, along the seal section towards the fold line, so that folding the strip along the first fold line and severing the scored section provides flexibility to the sidewall section, so that upon folding the sidewall section towards the seal section the sidewall section forms a concave boundary about the seal section.

Merchandise display guard and seal system

An attachment for cleaning accumulated debris from a rake. An ejector member is pivotally mounted on the rake and a plurality of clearing members eject debris clogging the tines. A handle is connected to an actuating rod that is connected to the ejector member. A return spring is active between the handle and the actuating rod to return the handle to a nominal position.

Growing community of inventors

Carlisle, MA, United States of America

Robert Vincent Martinez