University of Minnesota

Glaxo Inc.

Other

Robert Vince

Swati Sudhakar More

Mei Hua

Abbas Raza

James Melvin Beach

Christine Dreis

John Joseph Partridge

Robert Anthony Mook

John W Lackey

Mark L Peterson

Herbert T Nagasawa

William M Shannon

Rohit Singh

Ashish P Vartak

Steven Earl Patterson

Alexandre Monteil

Described herein is the use of a visible near infrared (VNIR) hyperspectral imaging system as a non-invasive diagnostic tool for early detection of Alzheimer's disease (AD). Also described herein is the use of a VNIR hyperspectral imaging system in high throughput screening of potential therapeutics against AD.

Hyperspectral imaging for early detection of Alzheimer's disease

In general, an imaging system to synchronously record a spatial image and a spectral image of a portion of the spatial image is described. In some examples, a beam splitter of the imaging system splits an optical beam, obtained from a viewing device, into a first split beam directed by the imaging system to a spatial camera and a second split beam directed by the imaging system to the entrance slit of an imaging spectrograph that is coupled to a spectral camera. An electronic apparatus synchronously triggers the spatial camera and the spectral camera to synchronously record a spatial image and a spectral image, respectively.

Spectral-spatial imaging device

The invention provides methods for producing analgesia in an animal comprising administering to the animal a compound of the formula Ia′, Ib′, Ic′, and Id′: and pharmaceutically acceptable salts thereof, wherein the variables A, R, R, R, R, R, L, X, Y, and Z have the meaning as described herein.

Therapeutic compounds

The invention provides compositions and methods for treating conditions associated with decreased activity of hydrogen sulfide.

Methods for the treatment of conditions related to hydrogen sulfide

Hyperspectral imaging for detection of transmissible spongiform encephalopathy

Hyperspectral imaging for detection of Alzheimer's disease

Disclosed herein are compounds of formula I: (I) or pharmaceutically acceptable salts thereof, wherein R, R, and Rmay any of the values defined herein, as well as compositions comprising such compounds. Also disclosed are methods for treating diseases including neurodegenerative disorders such as Parkinson's Disease and Alzheimer's Disease. 

Therapeutic compounds and methods

The invention provides methods and compositions for producing analgesia in an animal.

Use of Tosedostat and related compounds as analgesics

Described herein is the use of a visible near infrared (VNIR) hyperspectral imaging system as a non-invasive diagnostic tool for early detection of Parkinson's disease (PD). Also described herein is the use of a VNIR hyperspectral imaging system in high throughput screening of potential therapeutics against PD.

Hyperspectral imaging for detection of Parkinson's disease

The invention provides sunless tanning compositions comprising a compounds of formula (I): or a salt thereof as described herein as well as methods for tanning mammalian skin by contacting the skin with the compounds of formula (I) or compositions comprising compounds of formula (I).

Sunless tanning compounds and compositions

The invention provides compositions and methods for treating cyanide poisoning.

Growing community of inventors

Minneapolis, MN, United States of America

Robert Vince