Imtm Gmbh

Institut Fur Medizintechnologie Magdeburg (imtm) Gmbh

Ansorge, Siegfried

Neubert, Klaus

Gollnick, Harald

Zouboulis, Christos C.

Robert Vetter

Siegfried Ansorge

Klaus Neubert

Uwe Lendeckel

Dirk Reinhold

Harald Gollnick

Christos Zouboulis

Christos C Zouboulis

Klaus Martin-Luther-Universität Neubert

Dirk Uni Magdeburg Inst Immunologie Reinhold

Jürgen Martin-Luther-Universität Faust

Uwe Universität Magdeburg Inst Lendeckel

Provided are combinations of inhibitors of dipeptidyl peptidase IV (DP IV) and of enzymes having the same substrate specificity (DP IV-analogous enzymatic activity) and inhibitors of alanyl aminopeptidase (aminopeptidase N, APN) and of enzymes having the same substrate specificity (APN-analogous enzymatic activity) and use of the same to obtain a more than additive to superadditive inhibition for the treatment of arteriosclerosis, for the treatment of allergic reactions of the type I according to the Gell and Coombs classification and for the treatment of dermatological diseases with follicular and epidermal hyperkeratoses and an enhanced proliferation of keratinocytes.

Combined use of enzyme inhibitors and of pharmaceutical compositions thereof

The invention relates to a process for the-inhibition of the DNA synthesis necessary for the proliferation of human sebaceous cells (sebocytes) by the isolated or joint effect of inhibitors of alanyl aminopeptidase (APN) and dipetidyl peptidase IV (DP IV) expressed by these cells. The DNA synthesis (proliferation) of human sebaceous cells is inhibited by the administration of the inhibitors of APN and/or of DP IV depending on the dose. Our invention shows that, for a therapy and for a prevention of dermatological diseases with sebaceous hyperproliferation and modified conditions of differentiation, the application of inhibitors of the above-mentioned enzymes and of corresponding pharmaceutical preparations and dosage forms thereof is suitable.

Use of enzyme inhibitors of aminopeptidase N and/or dipeptidylpeptidase IV

Combination of inhibitors of dipeptidyl peptidase IV (DP IV) and enzymes having the same substrate specificity (DP IV-analogous enzymatic activity) and inhibitors of alanyl aminopeptidase (aminopeptidase N, APN) and of enzymes having the same substrate specificity (APN-analogous enzymatic activity) for a more than additive to superadditive inhibition for the treatment of arteriosclerosis, for the treatment of allergic reactions of the type I according to the Gell and Coombs classification and for the treatment of dermatological diseases with follicular and epidermal hyperkeratoses and an enhanced proliferation of keratinocytes.

Combinations of enzyme inhibitors and the use thereof

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Magdeburg, Germany

Robert Vetter