Nationwide Children's Hospital

Robert V Strouse

Christopher K Breuer

Narutoshi Hibino

Cameron Best

Yong Ung-Lee

Irina Buhimschi

Kara Rood

Jeremy Patterson

It has been established that optimizing cell seeding onto tissue engineering vascular grafts (TEVG) is associated with reduced inflammatory responses and reduced post-operative stenosis of TEVG. Cell seeding increased TEVG patency in a dose dependent manner, and TEVG patency improved when more cells were seeded, however duration of incubation time showed minimal effect on TEVG patency. Methods of engineering patient specific TEVG including optimal numbers of cells to maintain graft patency and reduce post-operative stenosis are provided. Closed, single-use customizable systems for seeding TEVG are also provided. Preferably the systems are custom-designed based on morphology of the patient specific graft, to enhance the efficacy of cell seeding.

Systems and methods for optimized patient specific tissue engineering vascular grafts

An apparatus and system for analyzing one or more points of interest. The apparatus includes a main support having first and second legs. The first and second legs extending transversely from the main support. The main support nests an imaging device capable of capturing an image of a point of interest during use. An imaging shroud is coupled to and extending from the first leg, the shroud having a first opening for surrounding the point of interest. A second opening in the shroud is positioned such that it extends to be within the main support for the passage of a captured image of the point of interest during use.

Portable image diagnostic apparatus and system

Growing community of inventors

Columbus, OH, United States of America

Robert V Strouse