University of Utah Research Foundation

Sorenson Pharmaceutical, Inc.

Robert V Petersen

Tsung-Min Hsu

James L Sorenson

Don Christy

Han-Chen Lee

A nail-permeable medication means is disclosed for delivering a medicament through nails, claws, hoofs, or other similar hardened tissue of dermal derivation. The nail-permeable medication means includes a proteolytic enzyme component which facilitates permeation of substances through the hardened nail or keratin tissue, and also includes a medicament component selected to treat a specific disease. The nail-permeable medication means is particularly useful for treating onychomycosis of the fingernail or toenail, and avoids the need for more drastic therapeutic modalities, such as removal of the nail.

Composition and method for treating diseased nails

A percutaneous drug delivery method and enhancement composition are disclosed. The method comprises applying an enzyme preparation containing suitable amounts of non-enzyme permeation enhancers, such as lactam compounds (e.g. 1-substituted-azacycloheptan-2-one), and propylene glycol to a localized area of skin for a predetermined amount of time to enhance that area of skin's permeability to selected drug(s); occluding the area of skin during the application; and then applying the selected drug(s) to the area of skin to allow the drug to penetrate through the skin and into the circulatory system of the animal. Greatly enhanced penetration of chemicals through the skin results from the described treatment.

Percutaneous drug delivery system

A percutaneous drug delivery system, method, and kit are disclosed. The method comprises applying an enzyme preparation to a localized area of skin for a predetermined amount of time to enhance that area of skin's permeability to selected drugs, occluding the area of skin during the application, and then applying the selected drug(s) to the area of skin to allow the drug to penetrate through the skin and into the circulatory system of the animal. Greatly enhanced penetration of chemicals through the skin results from the enzyme treatment.

Growing community of inventors

Murray, UT, United States of America

Robert V Petersen