Sandoz Gmbh

Robert V Coombs

Eugene E Galantay

William J Houlihan

Goetz E Hardtmann

The compounds are benz[f]indazoles, e.g., 3-(p-chlorophenyl)-1-methylbenz[f]indazole, and are useful as fertility control agents.

Benzindazoles

The compounds are 13-(lower)alkyl-9.alpha.-methyl-17.alpha.-propadienylgona-4-en-17.beta.-ol -3-ones and derivatives thereof, e.g. 9.alpha.-methyl-17.alpha.-propadienylestra-17.beta.-ol-3-one, and are useful as progestational agents.

9-.alpha.-methyl-steroids

Substituted naphtho [1,2-c] pyrazoles, e.g., 3-(4-pyridyl)-2H-naphtho[1,2-c]-pyrazole, are useful as non-estrogenic anti-fertility agents.

Substituted naphtho pyrazoles

The invention discloses 1-tertiary-butyl-3-morpholino-3-phenyl-2,1-benzisoxazolines having pharmacological activity in animals and useful, for example, as hypolipidemic agents. The compounds may be prepared by reacting a 1-tertiary-butyl-3-phenyl-2,1-benzisoxazolium quaternary salt, e.g., 1-tertiary-butyl-3-phenyl-2,1-benzisoxazolium tetrafluoroborate with morpholine. The 1-tertiary-butyl-3-phenyl-2,1-benzisoxazolium quaternary salt may be prepared by reaction of a corresponding 3-phenyl-2,1-benzisoxazole with tertiary-butanol in the presence of a strong inorganic acid.

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Chatham, NJ, United States of America

Robert V Coombs