Harvard College

Eisai R&d Management Co., Ltd.

Robert T Yu

Hans J Hansen

Francis Gerard Fang

Andrew G Myers

Lynn D Hawkins

Atsushi Endo

Peter Bertinato

Hyeong-wook Choi

Daniel Jonathan Smaltz

Jakub Svenda

Nicholas E Hill

Thomas Magauer

Sally T Ishizaka

Shawn Schiller

Roch Boivin

Sridhar Narayan

Hyeong Wook Choi

Matthew Mackey

Chikako Ogawa

Mingde Shan

Gregory Berger

Thomas Maguer

The present invention relates to trioxacarcin compounds of the formula: or pharmaceutically acceptable forms thereof; wherein R, R, R, R, R, R, R, R, and Rare as defined herein. The present invention also provides processes for preparing such compounds and intermediates thereto; pharmaceutical compositions comprising such compounds; and methods of use and treatment.

Trioxacarcins and uses thereof

The present invention relates to trioxacarcin compounds of the formula: (I) or pharmaceutically acceptable forms thereof; wherein R, R, R, R, R, R, R, R, and Rare as defined herein. The present invention also provides processes for preparing such compounds and intermediates thereto; pharmaceutical compositions comprising such compounds; and methods of use and treatment. 

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Somerville, MA, United States of America

Robert T Yu