Rutgers, The State University of New Jersey

Other

Wellgen, Inc.

Robert T Rosen

Geetha Ghai

Chi-Tang Ho

Kuang Yu Chen

Mou-Tuan Huang

Charles D Boyd

Katalin Csiszar

Slavik Dushenkov

Martin Lipkin

Shengmin Sang

Jin-Woo Jhoo

Nitin Telang

Robert S Dipaola

Naisheng Bai

Mohamed M Rafi

Mingfu Wang

Mou Tuan Huang

Chi-Tang H

Mohammed Rafi

Bret C Vastano

The present invention provides novel benzotropolone derivatives represented by the general formula: including neotheaflavate B and EGCGCa. The benzotropolone derivatives of the present invention are effective antioxidant and anti-inflammatory agents. The present invention also provides novel method of synthesizing benzotropolone compounds in high yields and method of treating inflammatory conditions using benzotropolone containing compounds.

Benzotropolone derivatives and modulation of inflammatory response

Compositions and methods for preventing and treating disease are provided. The compositions are extracts of black tea that include a mixture of theaflavin-3-gallate and theaflavin-3'-gallate.

Black tea extract for prevention of disease

Compositions and methods of inhibiting tumor cell growth and treating and preventing cancer are provided based on administration of an orange peel extract either alone or in combination with other phytochemicals.

Extracts of orange peel for prevention and treatment of cancer

Compositions and methods for prevention or treatment of disease are provided which comprise analogs of Resveratrol.

Resveratrol analogs for prevention of disease

Compositions and methods for preventing and treating cancer are provided that comprise extracts of or compounds isolated therefrom. The compounds of 1-O-acetylbritannilactone or 1,6-O,O-diacetylbritannilactone are isolated and used for inducing apoptosis in cells and for treating cancer in an animal. Induction of apoptosis comprises contacting cells with a composition comprising the compounds in an amount sufficient to induce Bcl-2 protein phosphorylation. Further, treatment of cancer in an animal comprises administering to an animal a composition comprising the compounds in an amount sufficient to induce Bcl-2 protein phosphorylation to treat the cancer.

Inducing cell apoptosis and treating cancer using 1-O-acetylbritannilactone or 1,6-O,O-diacetylbritannilactone

Compositions and methods are provided for prevention and treatment of cancer. The compositions comprise pure hydroxylated chalcone compounds of licorice root ( ) including 1-propanone-1-(2,4-dihydroxyphenyl)-3-hydroxy-3-(4&prime;-hydroxyphenyl).

Use of 1-propanone-1-(2,4-dihydroxyphenyl)-3-hydroxy-3-(4&prime;-hydroxyphenyl) as an anticarcinogenic agent

The invention relates to an assay system for screening nutraceuticals, i.e., foods or food substances that occur naturally, or that are produced during processing which are capable of modulating in a subject the expression of one or more genes associated with a disease or undesirable physical condition. The nutraceuticals identified by the screening assays can be incorporated into compositions which may be administered to a subject to treat or prevent a disease or undesirable condition, or otherwise to improve the health of the subject. The invention further provides methods for modifying the amount of nutraceuticals in raw and processed foods or food substances.

Methods of screening foods for nutraceuticals

A method useful for the treatment of itching is disclosed. The method comprises applying an effective amount a 1,4-naphthoquinone to the affected area of the skin. The 1,4-naphthoquinone is hydroxy or keto at the 2 position or the 3 position, or a juglone. A composition comprising an effective amount of the 1,4-naphthoquinone, and a kit for conducting the method are also provided.

Growing community of inventors

Monroe Township, NJ, United States of America

Robert T Rosen