Other

Cancer Technologies, Inc.

University Patents, Inc.

The University of Arizona

Research Corporation Technologies, Inc.

The Translational Genomics Research Institute

Supergen, Inc

Topical Technologies, Inc.

Amplimed, Inc.

Robert T Dorr

David S Alberts

Victor J Hruby

Norman D Levine

Mac E Hadley

William A Remers

Wayne L Cody

Elizabeth Sugg

Gary A Flynn

Laurence H Hurley

Evan M Hersh

Haiyong Han

Salah M Sami

Arthur Y Shaw

Russell L Spreier

Bhashyam Iyengar

A 2-aryl-pyridylazole compound and derivatives useful in slowing the growth of cancer cells are disclosed. Also disclosed are methods of synthesizing the compound, methods of using pharmaceutical compositions containing the compound as an ingredient to slow the growth of cancer cells, and methods of treating cancer patients with pharmaceutical compositions containing the compound as an ingredient.

Compounds, pharmaceutical compositions and methods of use of 2-aryl pyridylazoles

The present invention is directed to novel anti-cancer compounds of the formula.

Cyanoaziridines for treating cancer

A catheter apparatus includes a hollow needle having a first end and a sharpened tip at a second end. A catheter having a blunt end is telescopically received in the needle. A catheter hub is attached to the catheter and spaced from the blunt end. The catheter hub is disposed adjacent the needle hub in an elastomeric housing. A method of inserting a catheter in a patient's vein includes a step of providing a catheter apparatus in which the elastomeric housing biases the hubs, needle, and catheter in a rest position in which the catheter protrudes from the tip of the needle. The method also includes the steps of squeezing the housing to displace the catheter hub relative to the needle hub, causing the tip of the needle to protrude beyond the blunt end of the catheter, inserting the needle and catheter in the patients's vein, and releasing the housing to allow the catheter assembly to return to the rest position.

Catheter apparatus and method

A method for treating palmar-plantar erythrodysethesia syndrome includes applying to affected areas a therapeutically effective amount of a dimethyl sulfoxide solution.

Topical DMSO treatment for palmar-plantar erythrodysethesia

Methods, compositions and a kit for deactivating spills or leaks of HIV infected blood or anticancer drugs by applying to the leak or spill an aqueous solution containing calcium hypochlorite or sodium hypochlorite as the active ingredient. In order to thicken the aqueous solution and thus keep it from spreading beyond its intended area of application, the solution of calcium hypochlorite contains methylcellulose. In addition to chemically deactivating the active anticancer drug, the solution of the invention also effectively decolorizes it, thus preventing permanent stains on any surface or fabric with which the anticancer drug comes into contact.

Method for deactivating a contaminant

A salve includes a water-miscible, hydrophilic cream vehicle, 1-22% by weight a-DFMO, and no absorption enhancer. The salve is preferably contained in an ointment tube permanently sealed at one end to preclude exposure to light and air. The salve is applied as a preventative in an appropriate amount twice daily to skin exposed to actinic radiation. An initial application of a salve including 10% by weight A-DFMO is preferred to minimize the risk of skin irritation without compromising the therapeutic value of the salve. The salve shows no systemic uptake, thereby eliminating systemic toxicities that result from other techniques for administering the drug.

Topical application of .alpha.-DFMO for preventing skin cancer

Method and composition for deactivating HIV infected blood and for

1, 2-dihydro-3H-dibenzisoquinoline-1,3-dione anticancer agents

A pharmaceutically active composition comprising a pharmaceutically acceptable carrier and one or more alpha-MSH or analogues thereof for use in the stimulation of integumental melanocytes in vertebrates in order to bring about the production of melanin is disclosed.

Composition for stimulating integumental melanocytes

Instrument for measuring tumors

A method for stimulating integumental melanocytes by the topical application of alpha-MSH analogs, and compositions comprising said analogs for use in the method are described.

Method of stimulating melanocytes by topical application of analogs of

A needle assembly comprises a needle having a sharp point encased within and movable with respect to a sheath having a blunt end. A hub attached to the sheath has a recess therein for receiving a compressible member carried by an end of the needle having a collar thereon for engaging the compressible member. The compressible member retracts the point of the needle into the interior of the sheath to prevent contact of the point by user of the needle. When the needle assembly is attached to a syringe, or other instrument, the collar of the needle is engaged by a portion of the syringe and moved to compress the compressible member and expose the point of the needle for use.

Self-sheathing hypodermic needle

Method of stimulating integumental melanocytes by topical application of

An aspiration device for delivering a controlled dosage of a drug to a smoker's mouth and lungs comprises an elongated container adapted to be positioned within a cigarette or other smoking article adjacent the end intended to be held in the smoker's mouth. The container holds a supply of a drug which is aspirated directly into the smoker's mouth as a result of the suction applied by the smoker to the end of the cigarette. An air inlet port communicates with the outer surface of the cigarette and permits air to enter the container in response to the partial vacuum created by the applied suction. The drug held within the container is discharged through an exit orifice thereof which is coplanar with the end of the cigarette, so that mixing of the drug with the tobacco smoke occurs within the mouth of the smoker, at reduced temperature and lower smoke concentration. By appropriate selection of the size of the exit orifice from the container, the rate at which the drug is delivered can be controlled, so that an amount of drug proportional to the amount of smoke withdrawn from the cigarette or other smoking article can be delivered into the smoker's mouth.

Aspiration device for a smoking article

A venipunture or similar infusion device comprises a blunt-ended catheter telescopically received in a sharp-tipped hollow needle, the catheter and needle being connected respectively to associated hubs which are spring-biased toward each other. In passive condition, with the hubs substantially in contact, the blunt end of the catheter protrudes from the sharp tip of the needle. For insertion of the device into a vein or other tissue, a wedge attached to one of the hubs is manipulated to wedge the hubs, and the catheter and needle attached thereto, a sufficient distance apart to cause the sharp tip of the needle to protrude beyond the blunt end of the catheter. After insertion, release of the wedge permits the spring to return the hubs to passive condition, with the blunt end of the catheter protruding from the sharp tip of the needle. Thus, during the indwelling period, the sharp tip of the needle is effectively covered and can do no damage to a vein or other tissue in which it is inserted.

Growing community of inventors

Tucson, AZ, United States of America

Robert T Dorr