Merck + Co., Inc.

Pharm-eco Laboratories, Inc.

Robert Stevenson

Tesfaye Biftu

Tsung-Ying Shen

Thomas R Beattie

Emile Al-Farhan

San-Bao Hwang

Reem M Haider

Thomas W Doebber

Ahmed Hilmy

Milind P Sant

Disclosed is a method of preparing a compound represented by the following structural formula: ##STR1## and physiological salts thereof. R.sup.1 is --H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group. R.sup.2 is a substituted or unsubstituted 2-hydroxy-1-ethyl group. Ring A is a substituted or unsubstituted aryl group. Ring B is substituted or unsubstituted at position two. The method comprises reacting a substituted or unsubstituted aryl hydrazine or salt derived from a substituted or unsubstituted aryl hydrazine with a compound represented by the following structural formula: ##STR2##

Method for making substituted indoles

Analogs of 2,5-Diaryl tetrahydrofurans which were substituted or unsubstituted at 3,4-positions were prepared. These compounds are found to have potent and specific PAF (Platelet Activating Factor) antagonistic activities and thereby useful in the treatment of various diseases or disorders mediated by the PAF, for example, inflammation, cardiovascular disorder, asthma, lung edema, adult respiratory distress syndrome, pain, and aggregation of platelets.

Method of use of 2,5-diaryl tetrahydrofurans and analogs thereof as

Growing community of inventors

Lexington, MA, United States of America

Robert Stevenson