Menlo Care, Inc.

Oxular Limited

Other

Ethicon, Gmbh

Medtronic Vascular, Inc.

Cordis Corporation

Johnson & Johnson Gmbh

Transvascular, Inc.

Menlo Care Div of Ethicon, Inc.

Folde Inc.

Robert Steven Bley

Kevin H Van Bladel

Stanley R Conston

Joseph R Thomas

John P Lunsford

Loc X Phan

Daniel J Balbierz

John D Wallace

Ronald Kenichi Yamamoto

Ascher Shmulewitz

Robert L Wilcox

Jack M Walker

Tien Thuy Nguyen

Ronald K Yamamoto

Dillon Daniel Martinez

John H Burton

Sammy S Datwani

Ronald C Brown

Kevin Van Bladel

Young M Kang

MingYao Ding

Roy Singfatt Chin

Brad Michael Howarth

Adam Jonathan Frederick Stops

Ricky Barnett

The present invention provides a drug composition comprising particles comprising a biodegradable or bioerodable polymer and a drug, a soluble, biodegradable or bioerodible excipient, a bulking agent and a reconstitution aid. The invention also provides a pharmaceutical formulation and a unit dosage form of the pharmaceutical formulation. The invention provides methods of treatment of a disease or condition accordingly. The invention also provides a drug composition for use in a cannulation device.

Ophthalmic drug compositions

Described herein are various embodiments of flexible catheters comprising one or more flexibility regions. In one embodiment, a catheter comprises an elongate body having a proximal segment and a distal segment; a first lumen defined by the elongate body and configured for drainage of a liquid from a bodily region; and a plurality of flexibility regions on or in the distal segment of the elongate body. The plurality of flexibility regions, collectively, is configured to passively bend anteriorly. Further, at least one of the plurality of flexibility regions has a defined percent volume of material removed and a defined cut depth percentage. The features and arrangement of the flexibility regions described herein result in the catheter requiring reduced force during insertion into a bodily lumen.

Flexible catheters and related methods

The present invention provides a cannulation device for administering an active agent containing composition to the suprachoroidal space or supraciliary space. The invention provides methods of treatment of an ocular disease or condition accordingly. The invention also provides compositions for use in a method of treatment of an ocular disease or condition for delivery into the suprachoroidal space or supraciliary space.

Ophthalmic delivery device and ophthalmic drug compositions

Sterile lyophilized drug compositions and methods for treating ocular diseases or conditions

A device for controlled delivery of an injection material to tissue spaces of an eye that are not normally open, such as the subconjunctival space, the suprachoroidal space and the subretinal space. The device comprises an elongated body with a hollow cannula at the distal end, a slidable plunger at the proximal end, and a reservoir for the material to be injected residing between the cannula and the plunger. The plunger is mechanically coupled to a source of force such as a spring or pressurized gas reservoir such that an injection force is applied to the injection material within the device prior to delivery of the injection material into an eye. A valve that is normally closed to prevent flow of the injection material during application of the injection force is placed in the flow path between the cannula and reservoir. Due to the injection force placed on the injection material, actuation of the valve allows controlled flow from the reservoir through the cannula and into the tissue space.

Ophthalmic injection device

An improved device which attaches to the back of a lathe or workbench which provides variable positionability of a dust collector port or other accessories. The device utilizes a track with a sliding bracket and an adjustable arm attached to the sliding bracket. The improved device allows for better positioning of any accessory and does not inhibit any other operation at the work station.

Positionable mechanism for dust collection port and lathe accesories

Apparatus and methods for perfusing ischemic myocardium, and optionally, for reducing the load on a patient's left ventricle, are provided using a inlet conduit having an inlet end configured for insertion into an oxygenated blood source, including without limitation, the left atrium, left ventricle, aorta, pulmonary vein, subclavian artery, brachiocephalic artery, radial artery or femoral artery, coupled to an outlet conduit having an outlet end configured for insertion into the coronary venous vasculature via the coronary ostium. The inlet conduit may include a stylet or elastomeric sleeve that facilitates placement, while the outlet conduit may include a valve for limiting a peak pressure attained in the coronary venous system. A motor-driven or hydraulically-actuated pump optionally may be coupled in the flow path, and control circuitry provided to control the pump with a user selected duty cycle.

Apparatus for providing coronary retroperfusion and methods of use

A physiologically acceptable composition comprises a plurality of physiologically acceptable hydrogel particles which have been swollen in a water solution containing a low molecular weight water soluble organic compound, the solution having the ability to swell the particles. The concentration of the organic compound is such that the resulting particles can be inserted, without use of a carrier liquid utilizing a hand driven hypodermic syringe. The swollen hydrogel particles are substantially insoluble in body fluids. The composition is useful for treating urinary tract disorders.

Swollen hydrogel for sphincter augmentation

The present invention relates to a stiffening member, which is a stylet, that helps increase the fluid flow area within a catheter. In a preferred embodiment, the stylet is made of a single piece of flat rectangular stock that can be twisted to provide equal rigidity in all directions. A cross-section of the stylet reveals that the substantially flat rectangular shape of the stylet permits maximum fluid flow between the stylet and the catheter. This results in increased ease in manipulating and removing the stylet from the catheter. In addition, because the preferred embodiment of the stylet comprises a single element, it is easier to manufacture and should result in lower manufacturing costs. Moreover, the use of the present invention should also result in lower overall health-care costs.

Stiffening member to increase fluid flow within a medical device

A composition for injecting into tissues surrounding the urethra or ureter. It comprises a plurality of physiologically acceptable solid polymer particles dispersed in a physiologically acceptable biodissipatable liquid carrier. The polymer comprises a hydrophilic component and may also include a non-hydrophilic component. The polymer hydrates and swells to a predetermined volume as the liquid carrier dissipates. The composition is especially suitable in treating patients with urinary incontinence and patients with vesicoureteral reflux via injection into the tissues around the urethra or ureter.

Controlled expansion sphincter augmentation media

Apparatus and methods for perfusing ischemic myocardium are provided using a tubular member having an end region adapted to be disposed in a portion of a patient's venous vasculature. The end region includes a lumen and a valve in communication with the lumen that controls pressure within an occluded portion of the vasculature by venting excess blood at a location proximal of a point of occlusion of the vasculature via the valve. An occlusion element optionally may be provided in the end region that retains the tubular member within the patient's venous vasculature and occludes the flow of blow around the lumen.

Pressure-controlled continuous coronary sinus occlusion device and methods of use

The present invention is a medical device such as a stent in the form of an expandable mesh with an expandable polymer layer thereon. The mesh is metal or plastic. The polymer may be any of a variety of expandable polymers, which either expand upon hydration, or expand without significant resistance. The invention may be used, for example, as an expandable biliary, vascular, endotracheal, esophageal, or prostatic device.

Covered expanding mesh stent

In accordance with the invention, there are provided medical devices with incorporated shape memory systems that allow a polymeric medical device to be inserted in a first conformation or configuration and revert to a second conformation or configuration. The invention is useful in allowing the easy insertion or implantation of a device followed by expansion of the device in order to be retained without expulsion from a body cavity, for example. In another aspect of the invention there is provided a medical device, such as a ureteral stent, that includes comprising an elongated member having a proximal end portion and a distal end portion joined by a body portion. The elongated member has an initial outer diameter. A retention construction serves for retaining the member within a bodily cavity. The member is formulated of a physiologically acceptable polymer capable of hydrating and expanding from the initial member outer diameter to form a final member outer diameter. The device can assume differing shapes and can exhibit different degrees of softening at different places along its length and possess shape memory so that it can be inserted in a first conformation or configuration and revert to a second conformation or configuration upon the occurrence of a triggering event such as hydration.

Polymeric medical device systems having shape memory

A synthesis method is set forth for forming a physiologically acceptable composition comprising a plurality of physiologically acceptable hydrogel particles which have been swollen in a water solution containing a low molecular weight water soluble organic compound, the solution having the ability to swell the particles. The concentration of the organic compound is such that the resulting particles can be inserted, without use of a carrier liquid utilizing a hand driven hypodermic syringe. The swollen hydrogel particles are substantially insoluble in body fluids. The method comprises contacting not fully swollen hydrogel particles with the organic compound and with water.

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Menlo Park, CA, United States of America

Robert Steven Bley