Cancer Research Campaign Technology Limited

Robert Stanley McElhinney

Jane Kelly

Amanda Jean Watson

Joseph Anthony Rafferty

Geoffrey Paul Margison

Thomas Brian McMurry

Dorothy Josephine Donnelly

Rhoderick Hugh Elder

Mark Andrew Willington

Paul Murray

Christophe Carola

Joan Elizabeth McCormick

Mark Ross Middleton

The present invention provides certain 6-hetarylalkyloxy pyrimidine derivatives of formula II ##STR1## wherein R is (i) a cyclic group having at least one 5- or 6-membered heterocyclic ring, optionally with a carbocyclic or heterocyclic ring fused thereto, the or each heterocyclic ring having at least one hetero atom chosen from O, N, or S, or a substituted derivative thereof; or (ii) phenyl or a substituted derivative thereof,

Pyrimidine derivatives and guanine derivatives, and their use in

The present invention provides certain 6-hetarylalkyloxy pyrimidine derivatives of formula II ##STR1## wherein R is (i) a cyclic group having at least one 5- or 6-membered heterocyclic ring, optionally with a carbocyclic or heterocyclic ring fused thereto, the or each heterocyclic ring having at least one hetero atom chosen from O, N, or S, or a substituted derivative thereof; or (ii) phenyl or a substituted derivative thereof, R.sup.2 is selected from H, C.sub.1 -C.sub.5 alkyl, halogen or NH.sub.2, R.sup.4 and R.sup.5 which are the same or different are selected from H, NH.sub.2 or NO.sub.n where n=1 or 2, or R.sup.4 and R.sup.5 together with the pyrimidine ring form a 5-or 6-membered ring structure containing one or more heterocyclic atoms, and pharmaceutically acceptable salts thereof, exhibit the ability to deplete O.sup.6 -alkylguanine-DNA alkyltransferase (ATase) activity.

Pyrimidine and purine derivatives and their use in treating tumour cells

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Dublin, Ireland

Robert Stanley McElhinney