Memorial Sloan Kettering Cancer Center

University of California

Robert Soslow

Jonathan Braun

Madhuri Wadehra

Michael Berger

Sathima Natarajan

Douglas A Levine

Petar Jelinic

Provided are compositions and methods for the identification and treatment of ovarian cancers, such as small cell ovarian cancers, in particular small cell carcinoma of the ovary, hypercalcemic type (SCCOHT), which ovarian cancers are characterized by reduced SMARCA4 gene expression and/or protein function and, as a consequence, are sensitive to growth and/or survival inhibition by one or more compounds that restore SMARCA4 gene expression and/or protein function.

Compositions and methods for the diagnosis and treatment of ovarian cancers that are associated with reduced SMARCA4 gene expression or protein function

The present invention discloses methods of using epithelial membrane protein 2 (EMP2) as a biomarker for stratification of endometrial premalignancy, diagnosing, staging and imaging of endometrial neoplasia. Further, methods for identifying pharmaceutical/therapeutic modalities are described, including compositions which modulate glycolipid-enriched lipid raft microdomains (GEMs).

Methods for diagnosis and treatment of endometrial cancer

Growing community of inventors

New York, NY, United States of America

Robert Soslow