Akzona Incorporated

Baxter International Inc.

Baxter Healthcare Sa

Umc Utrecht Holding B.v.

Universiteit Utrecht Holding B.v.

Organon Teknika Bv

Akzo N.v.

Stichting Voor De Technische Wetenschappen

Universiteit Twente

Robert Smakman

Gerrit H Van Den Berg

Wilhelmus Everhardus Hennink

Henk P Blom

Wilhelmus Pannekeet

Cornelus Franciscus Van Nostrum

Karin Gerarda Frederika Gerritsen

Mitchell J Poss

Alex Odufu

Jacobus Adrianus Wilhelmus Jong

Kees Koerts

Yong Guo

Ilaria Geremia

Dimitrios Stamatialis

The present invention relates to a method for preparing a macromolecular composition comprising indene-derivatives. The invention also relates to the macromolecular compositions per se, and to methods of using the macromolecular compositions. The macromolecular compositions are useful for undergoing subsequent reactions with small molecules.

Macromolecular compositions comprising indene-derivatives, preparation thereof, and use thereof

Methods of producing macromolecular compositions and using same are provided. The method includes preparing a resin material; forming an acetyl group on the resin material; and oxidizing the acetyl group via a one-step reaction including reacting a sulfoxide and an acid with the acetyl group to form a ketoaldehyde group. The macromolecular compositions are capable of removing an effective amount of one or more constituents from a physiological solution, such as urea during dialysis therapy.

Macromolecular ketoaldehydes

A carbonyl groups containing macromolecular material which is suitable for use as a sorbent for ammonia, urea or amino compounds. It contains structural units having 3 or more, optionally hydrated vicinal carbonyl groups, preferably keto groups, the C-atoms of which may form part of a ring structure. Particularly, the ring structure contains 5-7 C-atoms, and at least 2 ring atoms may form part of an aromatic ring system. The starting material used may be made of a polymer of the same type as that used in the manufacture of ion exchange resins. The carbonyl group containing unit may form part of an independent compound, e.g., ninhydrin which may be physically bonded to the macromolecular material, but is preferably covalently bonded thereto.

Macromolecular carbonyl groups containing material suitable for use as

An apparatus for purifying blood has a blood compartment and a clearance compartment separated by a semi-permeable membrane. The apparatus includes a device containing a cation exchange resin charged with metal ions whose phosphates are insoluble in water. Metal salts of iron, aluminum, zirconium, lanthanum, thorium and tin are deposited on a cation exchange material and the charged cation exchange resin is contacted with dialysis liquid. The process of treating blood with the dialysis liquid is also contemplated.

Dialysis apparatus and process for controlling the phosphate level of

An apparatus for purifying blood has a blood compartment and a clearance compartment separated by a semi-permeable membrane. The apparatus includes a device containing a cation exchange resin charged with metal ions whose phosphates are insoluble in water. Metal salts of iron, aluminium, zirconium, lanthanum, thorium and tin are deposited on a cation exchange material and the charged cation exchange resin is contacted with dialysis liquid. The process of treating blood with the dialysis liquid is also contemplated.

Dialysis with ion exchange extraction of phosphates

A method for removing a weak acid from an aqueous solution containing said acid is disclosed. The method comprises contacting said aqueous solution with an anion exchanger containing both strongly basic and weakly basic groups, said exchanger having a matrix comprising a copolymer of styrene and not more than about 20%, by weight, of a cross-linking agent, from about 3% to about 90% of the total basic groups being strongly basic groups of the quaternary ammonium type having the structure --CH.sub.2 N.sup.+ R.sub.1 R.sub.2 R.sub.3, wherein R.sub.1, R.sub.2, and R.sub.3 are independently selected from the group consisting of --CH.sub.3, --C.sub.2 H.sub.5, and --C.sub.2 H.sub.4 OH, and the balance of the basic groups being weakly basic groups of the tertiary amine type.

Method for removing a weak acid from an aqueous solution

A process for removing an organic impurity from an aqueous solution is disclosed, said process comprising contacting the aqueous solution with an acid cation exchanger and subsequently with a polymer or polycondensate, which contains sulfur in the form of thiol groups bonded to carbon atoms.

Process for purifying an aqueous solution

Ferric ions are removed from a concentrated aqueous zinc solution having a pH value in the range of about 0 to about 1.3, by contacting the zinc solution with a cation exchange chelate resin containing aminocarboxylic acid and/or iminodicarboxylic acid groups.

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Nigtevecht, Netherlands

Robert Smakman