Pharmacia & Upjohn Company

Robert Shih-Liang Chao

Michael S Bergren

Michael J Dunn

Jeffrey L Havens

Lorraine Elisabeth Pena

William C Schinzer

Phil Bryan Bowman

Kenneth Paul Shephard

Gregory E Hardee

Azhwarsamy Jeganathan

Dale S Aldrich

Carolyn V Pesheck

Xuanqiang Yu

A highly storage-stable composition for vaginal administration of clindamycin is disclosed which is useful for the treatment of bacterial vaginosis. The composition is a vaginal suppository containing an antimicrobially effective amount of clindamycin dispersed in a Hard Fat NF suppository base. Hard Fat NF suppository bases provide a clindamycin product having long term storage stability while providing efficacy against bacterial vaginosis which is equivalent to clindamycin vaginal creams.

Intravaginal clindamycin ovule composition

Novel crystal forms of the fluoroquinolone, [S-(R*,S*)]-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[3-[1-(methylam ino)ethyl]-1-pyrrolidinyl]-4-oxo-3-quinolinecarboxylic acid are disclosed. The forms are characterized by one methanol solvate form, and three anhydrous polymorphic forms, of which, Form III exhibits greatest stability and decreased hygroscopicity.

Physically stable solid form of a fluoroquinolone

Crystalline ceftiofur free acid

Growing community of inventors

Portage, MI, United States of America

Robert Shih-Liang Chao