The Procter Gamble Company

Duke University

The University of Texas System

Ge Healthcare Bio-sciences Ab

Robert Scott Youngquist

John McMillan McIver

Mitchell Anthony deLong

Jun Xu

Robert Lloyd Binder

Lixin Lilly Zhang

Rosemarie Osborne

Mitchell Anthony DeLong

Charles Winston Saunders

Kevin John Mills

Ping Hu

Teresa DiColandrea

Kenton Duane Juhlin

Scott Michael Hartman

Alan David Willey

Vladimir Gartstein

Jean-Luc Maloisel

James Robert Schwartz

Jorge Max Sunkel

Ronnie Palmgren

Mary Jane Combs

Casey Patrick Kelly

John Erich Oblong

James Henry Saunders

David Joseph Eickhoff

Chinto Benjamin Gaw

Deborah Ruth Finlay

Charles Carson Bascom

Sancai Xie

Justin Angelo Caserta

Michael Glenn Davis

Jeanette Anthea Richards

Brian Wilson Howard

Makio Tamura

Thomas Larry Dawson

Lijuan Li

Jean Angela Jefferson

Thomas Woods Keough

Marta Lea Verhoff

Maria Liminga

Martha Jane Kolodzik

Brian Keith Fisher

Yungi Lee

Gary Richard Fuentes

Deborah Lade

Toshiyuki Iwata

Koji Takata

Jeffrey Kenneth Domsic

Robie Lynn Lucas

The present invention is directed to a method of treating skin and scalp comprising applying on the scalp or skin a composition comprising a scalp care active selected from the group consisting of 2-Pyridinol-N-oxide, a pyrithione or a polyvalent metal salt of pyrithione, one or more iron chelator having an A log P value of greater than or equal to 0.4 and mixtures therein; exposing the scalp and skin to electromagnetic radiation having wavelength from about 350 nm to about 500 nm and power from about about 0.1 mWatts/cmto about 1000 mWatts/cmand for a time period from about 2 seconds to about 5 minutes; wherein the antimicrobial treatment results in reduction of fungal growth as measured by the Fungal Growth Sensitivity Test of at least 50% compared to the dark sample.

Light augmented treatment method

A method for making a skin care composition by identifying connections between cosmetic agents and genes associated with one or more skin aging conditions. The method includes accessing a plurality of instances and at least one skin aging gene expression signature, comparing the at least one skin aging gene expression signature to the plurality of the instances, assigning a connectivity score to each instance based on the comparison and incorporating the cosmetic agent into a skin care composition when the connectivity score of the instance associated with the cosmetic agent has a negative correlation.

Method of making skin care compositions

The present invention is directed to a method for treating a hair disorder in a human or animal in need thereof, involving topically applying to the human or animal an effective amount of at least one 6-substituted 2-pyridinol N-oxide compound, a tautomer, or a cosmetically acceptable salt thereof wherein a hair count is increased by at least 0.5 hairs/cmand/or an increase the number of anagen hairs and maintain the number of telogen hairs when compared to a baseline and/or vehicle.

Method of treating a hair disorder with N-hydroxypyridinones

Methods and systems for determining functional relationships between a skin-active agent and a skin condition of interest, and methods and systems for identifying cosmetic agents effective for treatment of dandruff, as well as the use of agents identified by such methods and systems for the preparation of cosmetic compositions, personal care products, or both are provided. Methods for developing in vitro models of skin disease and models for specific skin diseases are also provided.

Systems, models and methods for identifying and evaluating skin-active agents effective for treating dandruff/seborrheic dermatitis

Methods and systems for constructing a gene expression signature representative of a number of biological conditions, systems and methods for determining functional relationships between a skin-active agent and skin conditions of interest, and methods and systems for identifying skin-active agents with broad spectrum activity are provided.

Systems, models and methods for identifying and evaluating skin-active agents effective for treating an array of skin disorders

Provided are methods and systems for determining functional relationships between a cosmetic agent and a hair biology condition of interest. Also provided are methods and systems for identifying cosmetic agents that affect a hair biology condition, as well as the use of agents identified by such methods and systems for the preparation of cosmetic compositions, personal care products, or both.

Systems and methods for identifying cosmetic agents for hair/scalp care compositions

A method for treating hair loss in mammals uses compositions containing 2-decarboxy-2-phosphinico prostaglandin derivatives. The compositions can be applied topically to the skin. The compositions can arrest hair loss, reverse hair loss, and promote hair growth. Compositions containing 2-decarboxy-2-phosphinico prostaglandin derivatives can also be used to lower intraocular pressure and treat bone disorders.

Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives

A method for treating hair loss in mammals uses compositions containing prostaglandin F analogs. The compositions can be applied topically to the skin. The compositions can arrest hair loss, reverse hair loss, and promote hair growth.

Compositions and methods for treating hair loss using non-naturally occurring prostaglandins

A system for identifying connections between a cosmetic agent and at least one gene associated with a skin aging condition. The system includes a computer readable medium having stored thereon a plurality of instances and a skin aging gene expression signature. Each instance comprises an ordered list of identifiers representing a plurality of differentially expressed genes generated as a result of contact between the cosmetic agent and a human fibroblast cell or a human keratinocyte cell. The computing device includes computer-readable instructions for accessing the plurality of instances and the skin aging gene expression signature stored on the computer readable medium, comparing each of the instances to the skin aging gene expression signature, and assigning a connectivity score to each of the instances based on the comparison.

Systems for identifying cosmetic agents for skin care compositions

The invention provides a method for improving hair biology, e.g., hair growth. The method comprises administering to a subject a monoamine oxidase inhibitor and a vasodilator, a zinc salt of a carboxylic acid, a xanthine compound, pyrithione or a salt thereof, saponin, tritapene, crataegolic acid, celastrol, asiatic acid, an inhibitor of 5-alpha-reductase, 1,4-methyl-4-azasteroid, an androgen receptor antagonist, azelaic acid or a derivate thereof, cyclosporin, triiodothyronine, diazoxide, retinoic acid, a prostaglandin analog, aminexil, carnitine tartrate, apigenin, procapil, or adenosine, in an amount effective to achieve a desired effect. The invention further provides a method of reducing or delaying the appearance of an age-related skin imperfection. The method comprises administering to the subject a composition comprising an MAO inhibitor. A kit for improving hair growth also is provided.

Use of monoamine oxidase inhibitors to improve epithelial biology

The present invention is directed to a method of inhibiting aconitase activity of fungal cells in an individual, the method comprising administering an inhibitor of aconitase activity to the fungal cell in an amount effective to inhibit activity of aconitase by said fungal cells.

Inhibition of microbial growth by aconitase inhibition

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Growing community of inventors

Mason, OH, United States of America

Robert Scott Youngquist