Unl Holdings LLC

Unitract Syringe Pty Ltd

Synolus Medical, Inc.

Robert Scott Russo

Brandon J McKee

Jyoti Gupta

Daniel A Heinsbergen

John W Carosi

Kevin Lee Bokelman

Gautam N Shetty

Christian Perry Brandt

Ramin Mojdehbakhsh

Dinesh Panneerselvam

Bryan Frederick Bell, Jr

Eduardo Ho

Lawton Laurence

Christopher Charles Rafferty

Shaun Robert Devitt

Tod Brenner

Jeffrey M Johnson

Aaron M Weir

Lance W Wetzel

Alexis Marie Adolphe Dechelette

Christian P Brandt

Brandon J Mckee

Tod H Brenner

A wearable injector for automated delivery of biologic drugs that solves the problem of high volume and high viscosity drug administration by providing a device that can be worn by the patient through use of an adhesive patch to deliver the medication slowly over extended periods of time.

Wearable injector

Needle assemblies for retractable needle syringes include a needle, a needle seal, and a needle retainer, wherein the needle includes one or more barbs substantially at its proximal end. The needle retainer engages an optional needle-over-mold component that is fixedly attached to the needle. The needle-over-mold may be connected to the distal surface of the needle seal and may travel, such as by being a couple component, with the needle during the operation of the syringe. A safety syringe includes a barrel having a needle assembly mounted at a distal end and a plunger assembly mounted at a proximal end. A drug may be contained in a drug chamber of barrel, between the plunger assembly and needle assembly, proximally of the needle seal for drug delivery to a user. The plunger assembly includes a plunger seal having a needle-engaging portion to capture the needle at the barb for retraction.

Needle capture retractable needle safety syringes

An expanding plunger rod () for a syringe (). The expanding plunger rod is configured to transition from a packaged configuration for packaging to an expanded configuration for operation. The expanding plunger rod comprises a substantially cylindrical outer sleeve () having a closed-off bottom end () and an open upper end (). The expanding plunger includes an inner rod () having a lower end () and an upper end (). The inner rod is slidably disposed coaxially within the outer sleeve. In the packaged configuration, the inner rod is nested within the outer sleeve. In the expanded configuration, the inner rod is disposed substantially axially above the outer sleeve, and the inner rod is configured to lock axially in place so as to prevent transition from the expanded configuration to the packaged configuration.

Expanding plunger rods for syringes

Provided herein is a fluid pathway connection assembly, e.g., for connecting a fluid flowpath within a drug delivery device for delivery of a medicament to a target site. The fluid pathway connection assembly comprises a hollow needle piercing member, a sleeve fixedly engaged with the piercing member and a pierceable seal configured to sealingly engage the piercing member or the sleeve. Upon, sealing engagement, the piercing member or the sleeve and the pierceable seal form a volume within which a portion of the piercing member is disposed. The fluid pathway connection assembly is activated by relative movement between the piercing member and the pierceable seal and activation causes the piercing member to pierce the pierceable seal, thereby establishing a fluid flowpath through the pierceable seal. Upon incorporation of the assembly into a sealed fluid flowpath, the volume is isolated from the environment and maintains the sterile condition of the portion of the piercing member disposed therein. Also provided herein are drug delivery pumps and methods of operating and assembling the assemblies and pumps described herein.

Drug delivery device and method for connecting a fluid flowpath

A vial adapter is provided for interconnecting a vial having a closure and a fluid delivery device such as a safety syringe. The vial adapter comprises an adapter housing having a base, a shroud extending or projecting from the base and a cannula extending or projecting from the base for penetrating a rubber seal on the vial closure to thereby establish fluid communication between the vial and the vial adapter. The shroud may comprise a plurality of latitudinal slits or windows within each of which resides a flexion arm connected to the shroud, each flexion arm capable of engaging and/or retaining vial closures of any of a variety of different sizes. The vial adapter may comprise a conduit tip in fluid communication with the cannula to allow transfer of fluid to or from the safety syringe while also preventing inadvertent activation of a safety syringe needle retraction mechanism.

Vial adapters

An expanding plunger rod for a syringe is configured to transition from a packaged configuration to an expanded configuration for operation. The rod includes a substantially cylindrical outer sleeve having a closed-off bottom end and an open upper end, and an inner rod having a lower end and an upper end. The inner rod is slidably disposed coaxially within the outer sleeve. In the packaged configuration, the inner rod is nested within the outer sleeve. In the expanded configuration, the inner rod is disposed substantially axially above the outer sleeve, and the inner rod locks axially in place to prevent transition from the expanded to the packaged configuration.

A barrel adapter for a syringe having a barrel and plunger. The adapter comprises a barrel tip and a needle retraction mechanism having a needle subassembly with a needle and a lumen, actuator subassembly, and biasing member. The needle subassembly moves from an injection to a retracted position within the barrel tip. The actuator subassembly includes a retainer connected to the barrel tip, a stylet held in a stylet disc, and a prong passing into the retainer. The stylet slides within the needle lumen and is spaced from the needle tip in the injection position. The biasing member biases the NOM from the retainer. A locking arrangement compresses the biasing member when locked and releases the biasing member when actuated by depression of the plunger, which moves the prong against the retainer. The biasing member moves the needle and stylet from the injection position to the retracted position when released.

Devices for targeted delivery of therapeutic implants

The present embodiments provide for a syringe and a retraction plunger assembly configured to accept various retractable needle assemblies, which are capable of cooperating to provide a retraction safety syringe. In particular, the syringe includes a barrel and a retraction plunger assembly comprising a control unit attached to a plunger and releasably engaged to a housing, and at least one biasing means disposed within the plunger assembly. Upon completion of dose delivery via a retractable needle, the control unit disengages from housing and the biasing member retracts the plunger and a connected needle into the barrel. Various elements are configured to prevent further use of the syringe. The control unit can be used to control a rate of needle retraction.

Selectable needle syringe with retraction plunger

Barrel adapters for safety syringes include a barrel and a plunger assembly adapted to move within the barrel, a barrel tip adapted to be sealingly engaged with a distal end of the barrel and a needle retraction mechanism barrel having a needle subassembly and an actuator subassembly. The needle subassembly includes a needle, and a needle-over-mold (NOM) through which the needle extends. The needle subassembly is disposed at least partially within the barrel tip, and adapted to move from an injection position in which the needle extends from a distal end of the barrel tip to a retracted position in which the needle is disposed within at least one of the barrel tip or the barrel. The actuator subassembly includes a needle seal, a push-bar, and an actuator surface. The needle retraction mechanism barrel includes a biasing member and an actuable locking arrangement. A syringe includes such barrel adapters.

Retractable needle adapters and safety syringes

Barrel adapters for safety syringes include a barrel and a plunger assembly adapted to move within the barrel, a barrel tip adapted to be sealingly engaged with a distal end of the barrel and a needle retraction mechanism having a needle subassembly and an actuator subassembly. The needle subassembly includes a needle, and a needle-over-mold (NOM) through which the needle extends. The needle subassembly is disposed at least partially within the barrel tip, and adapted to move from an injection position in which the needle extends from a distal end of the barrel tip to a retracted position in which the needle is disposed within at least one of the barrel tip or the barrel. The actuator subassembly includes a needle seal, a push-bar, and an actuator surface. The needle retraction mechanism includes a biasing member and an actuable locking arrangement. A syringe includes such barrel adapters.

Growing community of inventors

Gettysburg, PA, United States of America

Robert Scott Russo