Ascendis Pharma A/s

Ascendis Pharma Inc.

Complex Biosystems Gmbh

Ascendis Pharma Growth Disorders A/s

Robert Schnepf

Harald Rau

Ulrich Hersel

Thomas Wegge

Dirk Vetter

A polymeric prodrug composition including a hydrogel, a biologically active moiety and a reversible prodrug linker. The prodrug linker covalently links the hydrogel and the biologically active moiety at a position and the hydrogel has a plurality of pores with openings on its surface. The diameter of the pores is larger than that of the biologically active moiety at least at all points of the pore between at least one of the openings and the position of the biologically active moiety.

Hydrogel formulations

A cascade carrier linked prodrug is described comprising a biologically active moiety and a masking group having at least one nucleophile and being distinct from the carrier.

Polymeric prodrug with self-immolative linker

The application relates to a composition comprising a hyperbranched polymer attached to a core and a biologically active moiety. The biologically active moiety is attached to the core by means of a substantially non-enzymatically cleavable linker L. The composition can be used to deliver the biologically active moiety to its target.

Protein-proteophore complexes

A cascade carrier linked prodrug is described which comprises a biologically active moiety and a masking group having at least one nucleophile and being distinct from the carrier.

Growing community of inventors

Dossenheim, Germany

Robert Schnepf