Boston Scientific Scimed, Inc.

Cytyc Corporation

Scimed Life Systems, Inc.

Windy Hill Medical, Inc.

Boston Scientific Corporation

Robert Sakal

Gary B McAlister

Ben Morris

Hal Watts

German Trabada

Meghan Brennan

Marc O Schurr

Gerhard F Buess

Greg R Furnish

Russell F Durgin, Jr

Daniel Kalanovic

Charles H Whatley, Jr

Russell Francis Durgin

David T Hung

Kurt Geitz

Simon M Furnish

Todd A Hall

Steven A Scampini

Kevin Patenaude

Douglas M Macarthur

Kurt A E Geitz

Nathan P Wood

Ellen E Sheets

Patrick McCormick

Indi Gunasekara

Mark Girardi

Steve Scampini

Mark E Girardi

Jr Russell F Durgin

The present invention relates to devices, and methods for using the devices, to create and secure a tissue fold during an endoluminal medical procedure. The devices and methods may be used for folding and securing, for example, a fundus wall onto an esophagus wall or esophageal tissue in the region of the lower esophageal sphincter (LES) to reduce the diameter of the esophagus opening in that region. One aspect of the invention includes forming the tissue fold by closing a grasping arm that is pivotably connected to an overtube that has been positioned at the juncture of the fundus wall and esophagus wall. A further aspect of the invention includes tissue clips configured to be inserted and positioned through an endoluminal device.

Methods and devices for folding and securing tissue

An endoluminal access system for accessing a body lumen includes a guide track which, when in an operative position, extends through a body lumen to a desired location therewithin and a modular device selectively coupleable to the guide track, the modular device including a drive mechanism for engaging the guide track to move the modular device along the guide track within the body lumen. A method of resecting tissue from a site within a body includes the steps of inserting a guide track to a desired location within the body lumen, coupling a modular device to a proximal end of the guide track and actuating a motor mounted within the modular device to drive the modular device distally along the guide track to the site, drawing tissue at the site into the modular device in combination with the steps of coupling together a portion of tissue adjacent to the site, resecting the tissue from the site and actuating the motor to drive the modular device proximally to withdraw the modular device from the body lumen.

Endoluminal access devices and related methods of use

An endoluminal access system for accessing a body lumen, comprises a guide track which, when in an operative position, extends through a body lumen to a desired location therewithin and a modular device selectively coupleable to the guide track, the modular device including a drive mechanism for engaging the guide track to move the modular device along the guide track within the body lumen. A method of resecting tissue from a site within a body comprises the steps of inserting a guide track to a desired location within the body lumen, coupling a modular device to a proximal end of the guide track and actuating a motor mounted within the modular device to drive the modular device distally along the guide track to the site, drawing tissue at the site into the modular device in combination with the steps of coupling together a portion of tissue adjacent to the site, resecting the tissue from the site and actuating the motor to drive the modular device proximally to withdraw the modular device from the body lumen.

A modular device for tissue resection includes a housing, a motor, a tissue receiving chamber, a grabbing mechanism and a resection mechanism. The housing includes a guide track receiving lumen extending therethrough. The motor is mounted within the housing. The motor is selectively engageable with a guide track received within the guide track lumen to move the modular device therealong. The tissue receiving chamber is formed within the housing. The grabbing mechanism draws a selected portion of tissue into the tissue receiving chamber. The resection mechanism resects the selected portion of tissue.

A stapling unit for use with an endoscopic stapling system adapted to be advanced along an endoscope to a predetermined location within a body lumen to staple the portion of tissue, as part of an occlusal or full thickness resectioning procedure. The stapling unit comprises a first casing having a distal end, a proximal end and a stapling device mounted thereto adjacent to a first window extending through a periphery of the first casing. The invention includes methods for the stapling, severing and removal of tissue by using the device.

Stapling and cutting in resectioning for full thickness resection devices

Sample vials and methods of processing the sample vials are provided. The sample vial comprises a vial container, a sample collection chamber within the vial container, a vial cap configured to be mated with the vial container to enclose the collection chamber, an aliquot chamber, which may be carried by the vial cap or the vial container, and a valve mechanism for selectively sealing and unsealing the aliquot chamber from the collection chamber. The method may comprise flowing an aliquot of the sample from the collection chamber while the sample within the collection chamber is isolated from an environment exterior to the vial, sealing the aliquot chamber from the collection chamber to isolate the aliquot sample from the remaining sample portion, and transferring at least some of the remaining sample portion from the collection chamber to a microscope slide while the aliquot chamber is sealed from the collection chamber. The method further comprises reserving the slide for cytological screening of the sample, and reserving the aliquot sample for deoxynucleic acid (DNA) testing.

Method and apparatus for obtaining aliquot from liquid-based cytological sample

Vials used for obtaining an aliquot of a biological sample are provided. Also provided are method of using the vials and instruments to obtain an aliquot of a biological sample.

Vials and apparatus for obtaining an aliquot of a sample

A method of fixing a biological sample on a slide for cytological analysis, includes transferring a sample to a slide, applying a material having a slide-fixing amount of an inactivated, fixative to the slide, and activating the fixative. By way of example, the material may comprise a tape impregnated with the inactivated fixative, which tape may be removed from the slide after the fixative is activated.

Methods for fixing cytological samples

The invention provides methods that increase retrievable cells from ductal fluid of a patient. Ductal fluid typically contains ductal epithelial cells and other markers that can aid in identifying a breast condition, including breast cancer and precancer.

Increasing retrievable cells from a breast duct

A ductal access device is provided for accessing a breast duct and collecting biological material from within the duct. The access device may include an elongated member having an outer diameter sized for positioning within the breast duct and an internal lumen for infusing a fluid into the breast duct and collecting fluid from the breast duct. The elongated member may include a central axis extending through the internal lumen and a different axis being parallel to the central axis defining an off-axis configuration. An elongated distal tip extends beyond the distal end of the internal lumen and along the different axis. The elongated distal tip has a closed distal end for navigating within the breast duct. The elongated distal tip may include an internal passageway that is sized to slidiably or removably receive an elongated introducer.

Ductal lavage catheter having an off-axis tip

A carrier for slide processing comprises a plurality of first locations, each configured to hold a vial containing a biological sample, and a corresponding plurality of second locations, each configured to hold a slide.

Growing community of inventors

Bolton, MA, United States of America

Robert Sakal