Angio-medical Corp.

Boston University

Esrac Computer Corporation

Robert S Sinn

Nicholas Catsimpoolas

Robert McCluer

Ahmad R Kamarei

Ann L Griffith

James Evans

Michael I Klibaner

Sandor Szabo

Takashi Mise

Meryl S Rubin

Joseph Lane

Ganglioside mixtures and/or lipid mixtures e.g. from brain and omentum, are found to be effective to treat peptic ulcers.

Composition and method for treatment of gastric and duodenal ulcers and

Factors isolated from omental extracts are used to promote bone healing, for example in fractures in mammals.

Method for healing bone damage

Lipid material or ganglioside from mammalian sources e.g. bovine and porcine brain or omentum is used to treat peptic ulcers.

Method for the treatment of gastric ulcer

A method for enhancing angiogenesis and/or blood vascular perfusion in mammals by administering a pharmacologically effective amount of specific angiogenically active non-ionic, anionic, cationic and zwitterionic amphiphilic compounds. An angiogenically effective amount of the angiogenically active compound digitonin is in the range of at least 1.25 microgram to at least 200 microgram of digitonin. The range including enhancement of vascular perfusion is up to 50 mg of digitonin.

Angiogenic and blood perfusion inducing properties of amphiphilic

A method for causing or increasing angiogenesis is described. The method involves administering to a subject, such as a human being in need of angiogenesis an angiogenically effective amount of an angiogenically effective, pharmaceutically acceptable oligosaccharide or mixture of oligosaccharides.

Method for provoking angiogenesis by administration of angiogenically

Compositions which contain lipid containing molecules possessing angiogenic activity are disclosed. The lipid containing molecules have been found in mammalian tissue, particularly the omentum, of various animals. Additionally, known lipids, such as gangliosides, are unexpectedly found to possess angiogenic activity. A method for obtaining the omentum-derived lipids, and for use of these and known lipids, are disclosed as well.

Method for enhancing angiogenesis with lipid containing molecules

36 Lipid extracts and lipid fractions from mammalian omenta containing mostly lipids are used cosmetically for skin conditions, skin care and cosmetic products which products have skin softening applications without skin irritation, greasiness or mutagenic effect. These materials with and without ganglioside are used for skin conditions such as keratosis, white spots and the like.

Lipids from omentum and methods for cosmetic use

Animal or plant derived materials are prepared for extraction of desired substances therefrom by grinding said materials at or below their Brittleness Temperature. This treatment allows fracture of the materials into small particles with high surface area to volume, as well as high volume to mass ratios, and disrupts membranes of tissues, organs, cells or organelles which would otherwise prevent or limit separation of desired biomolecules.

Method for extracting a substance from animal derived material

Lipid containing molecules and compositions, including gangliosides and omental tissue extracts had previously been found to be effective in increasing angiogenesis. It has now been found that these same materials cause increased localized perfusion in mammals. A method for providing increased perfusion, using these compositions, is presented herein.

Increased vascular perfusion following administration of lipids

Omental lipid fractions accelerate wound healing especially as to epithelialization in mammals.

Method for enhancement of healing of epithelial wounds in mammals

Compositions containing ganglioside molecules with enhanced angiogenic

Apparatus and method are set forth for calculating a comparative speed rating for an entrant in a race such as a horserace so that the entrants performance can be compared with the performance of other entrants. The speed rating is determined in accordance with a formula which is based on a linear relationship between speed and distance over a particular distance for a particular class of entrant and where the speed rating for an entrant other than the winner is determined over the actual distance covered by the non-winning entrant in the same time as the winner. The specific equation to determine the speed rating is as follows: ##EQU1## Where f is the length of the race in furlongs Where L is the number of lengths horse was behind the winner

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New York, NY, United States of America

Robert S Sinn