Other

Ablation Products LLC

Gynelab Products, Inc.

Ethicon, Gmbh

Gynelab, Inc.

Neuwirth, Robert S.

Robert S Neuwirth

Lee R Bolduc

Michel Gensini

Bolduc R Bolduc

The present invention pertains to silver ion bearing carriers useful in treating monorrhagia of a mammalian uterus, comprising a physiologically inert, flexible earner, e.g., a coil, bearing a tissue cauterizing amount of a silver ion. Silver ions are delivered to the endometrium and cause necrosis of the endometrial tissue. The silver ions remaining within the uterine cavity can then be neutralized with a sodium chloride solution delivered to the uterus e.g., by catheter, and the carrier recovered from the uterus.

Silver ion delivery platform

A method for inducing Fallopian tube blockage as a means for female contraception comprises contacting the inner surface tissue of a Fallopian tube with a silver nitrate bearing substrate and delivering an amount of silver nitrate to the tissue sufficient to induce blockage of the Fallopian tube. At least one silver nitrate bearing bead is introduced through the uterine opening of the Fallopian tube by use of a catheter or other device suitable for manipulating the bead. Alternatively, a plurality of beads can be introduced into the Fallopian tube. In a preferred embodiment, one or more silver nitrate bearing beads are arranged on a string to facilitate later removal of the beads. The method of the present invention delivers an amount of silver nitrate to the tissue sufficient to cause tissue necrosis and blockage of the Fallopian tube.

Occlusion of fallopian tubes

A delivery vehicle for a silver ion source such as silver nitrate and the like, suitable for use in the treatment of menorrhagia, comprises a plurality of physiologically inert beads bearing a tissue cauterizing amount of a silver ion source. Preferably the beads are made of a physiologically inert polymer, ceramic or stainless steel. The silver ion source preferably is silver nitrate and can be substantially pure silver nitrate, or can comprise silver nitrate in combination with a physiologically tolerable binder or a diluent. Suitable binders include physiologically tolerable synthetic polymeric binders, polysaccharide binders, and the like. Diluents can include other salt materials such as potassium nitrate. The beads are useful in treating menorrhagia of a mammalian uterus. The beads can be delivered to the uterus via a catheter, and are distributed throughout the uterine cavity by uterine massage or like expedient. Silver ions are delivered to the endometrium and cause necrosis of the endometrial tissue. The silver ions remaining within the uterine cavity can then be neutralized with a sodium chloride solution delivered to the uterus e.g., by catheter, and the beads recovered from the uterus.

Method for treating menorrhagia

Delivery vehicle for silver ions

A method and composition for effecting chemical necrosis of a tissue lining of a mammalian body cavity, particularly a uterine endometrium, by delivering a caustic tissue necrosing composition, e.g., a silver nitrate and dextran paste, to the tissue to be necrosed and allowing the paste to remain in contact with the target tissue for a period of time sufficient to chemically necrose substantially the entirety of the tissue lining, and then contacting the caustic composition with a deactivating agent, e.g., an aqueous sodium chloride solution, thereby rendering the caustic composition non-caustic, and then rinsing the cavity. Compositions and methods for delivering medicaments are also disclosed.

Intrauterine chemical necrosing method and composition

A method and composition for effecting necrosis of a tissue lining of a mammalian body cavity, particularly a uterine endometrium, by introducing an applicator comprising a hysteroscope housing a first and a second catheter connected to a catheter into the uterus, distending the uterus by introducing CO,gas under pressure, delivering a silver nitrate paste to the endometrium through the first catheter and allowing the paste to remain a sufficient amount of time to substantially cauterize the entirety of the tissue lining, particularly the endometrium and delivering an aqueous sodium chloride solution to the uterus through the second catheter thereby neutralizing the silver nitrate and rinsing the uterine cavity.

Intrauterine chemical cauterizing method and composition

Intrauterine chemical necrosing method, composition, and apparatus

A method and apparatus for effecting necrosis of a tissue lining of a mammalian body cavity, particularly a uterine endometrium, by introducing an applicator comprising a distendable bladder connected to a catheter into the uterus, distending the bladder by introducing a non-toxic fluid under pressure, heating the fluid by means located internal to the bladder to a temperature of 190.degree. to 215.degree. F. and preferably 210.degree. F. for a period of 4 to 12 minutes and preferably 6 minutes and regulating said apparatus by means located external to the uterus, thereby cauterizing substantially the entirety of the tissue lining, particularly the endometrium. An agitator circulates the fluid within the distendable bladder to help keep the fluid at a uniform temperature.

Heated ballon medical apparatus with fluid agitating means

A method and apparatus for effecting necrosis of a tissue lining of a mammalian body cavity, particularly a uterine endometrium, by introducing an applicator comprising a distendable bladder connected to a catheter into the uterus, distending the bladder by introducing a non-toxic fluid under pressure, cooling the fluid by means located internal to the bladder to a temperature below 32.degree. F. for a period of about 4 to about 12 minutes and preferably about 6 minutes, thereby cauterizing substantially the entirety of the tissue lining, particularly the endometrium.

Intrauterine cryoablation cauterizing apparatus and method

A method and apparatus for necrosing tissue are disclosed. Also disclosed are a method and apparatus for treatment of urinary neck blockage and benign prostate hypertrophy. A catheter provided with a heating means and an inflatable balloon is inserted into the urethra so that the heating means is in proximity to the prostate gland and the inflatable bladder attached to the end of the catheter protrudes into the urinary bladder. The bladder is inflated in the urinary bladder to facilitate positioning of the heating means. The heating means is positioned and is then heated for a period of time sufficient to cause necrosis of the tissue lining of the prostate.

Tissue necrosing apparatus and method for using same including treatment

Heated balloon medical apparatus with fluid agitating means

A method for a laparoscopic cholecystostomy and prostate or gallbladder ablation is disclosed wherein a bladder catheter is inserted into the prostate or gallbladder then heated for a period sufficient to cause cauterization necrosis of the tissue lining of the prostate of gallbladder. Subsequently, the prostate or gallbladder is allowed to drain and is then removed. An apparatus for performing the procedure and a procedure and apparatus for treatment of benign prostate hypertrophy are also disclosed.

Cauterizing apparatus and method for laparoscopic cholecystostomy,

A method and apparatus for effecting necrosis of a tissue lining of a mammalian body cavity, particularly a uterine endometrium, by introducing an applicator comprising a distendable bladder connected to a catheter into the uterus, distending the bladder by introducing a non-toxic fluid under pressure, heating the fluid by means located internal to the bladder to a temperature of 190.about. to 215.about.F. and preferably 210.about.F. for a period of 4 to 12 minutes and preferably 6 minutes and regulating said apparatus by means located external to the uterus, thereby cauterizing substantially the entirety of the tissue lining, particularly the endometrium.

Intrauterine cauterizing method

A method and apparatus for effecting necrosis of a tissue lining of a mammalian body cavity, particularly a uterine endometrium, by introducing an applicator comprising a distendable bladder connected to a catheter into the uterus, distending the bladder by introducing a non-toxic fluid under pressure, heating the fluid by means located internal to the bladder to a temperature of 190.degree. to 215.degree. F. and preferably 210.degree. F. for a period of 4 to 12 minutes and preferably 6 minutes and regulating said apparatus by means located external to the uterus, thereby cauterizing substantially the entirety of the tissue lining, particularly the endometrium.

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Englewood, NJ, United States of America

Robert S Neuwirth