Nationwide Children's Hospital, Inc.

University of Oklahoma

Children's Hospital

Children's Hosptial Inc.

Robert S Munson, Jr

Lauren Opremcak Bakaletz

David W Dyer

The invention described herein relates to a() regulon encoding type IV pili. In particular, the invention relates to type IV pili from nontypeable(NTHi) and fromstrains a, b, c, e and f. The invention provides isolatedpilus polynucleotides and polypeptides encoded by the polynucleotides as well as polynucleotides and polypeptides encoded by the polynucleotides involved in the assembly/disassembly of the structure. The invention also relates to uses of these polynucleotides and/or polypeptides including methods for eliciting an immune response toand methods of treating and preventingrelated pathological conditions.

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The invention relates to the polynucleotide sequence of a nontypeable strain of(NTHi) and polypeptides encoded by the polynucleotides and uses thereof. The invention also relates to NTHi genes which are upregulated during or in response to NTHi infection of the middle ear and/or the nasopharynx.

The invention described herein relates to a chimeric protein comprising the NTHi twitching pilus major subunit protein (PilA) presenting a portion of the NTHi OMP P5 protein. The invention provides for vaccine compositions comprising the recombinant chimeric protein and methods of eliciting an immune response using the recombinant chimeric proteins of the invention.

The invention relates to the polynucleotide sequence of a nontypeable stain of(NTHi) and polypeptides encoded by the polynucleotides and uses thereof. The invention also relates to NTHi genes which are upregulated during or in response to NTHi infection of the middle ear and/or the nasopharynx.

The invention described herein relates to a() regulon encoding type IV pili. In particular, the invention relates to type pili from nontypeable(NTHi) and fromstrains a, b, c, e and f. The invention provides isolatedpilus polynucleotides and polypeptides encoded by the polynucleotides as well as polynucleotides and polypeptides encoded by the polynucleotides involved in the assembly/disassembly of the structure. The invention also relates to uses of these polynucleotides and/or polypeptides including methods for eliciting an immune response toand methods of treating and preventingrelated pathological conditions.

The invention relates to a mutation within the sap operon of an avirulent clone of a nontypeable strain of(NTHi). The invention also relates to the NTHi sap operon genes and the polypeptides encoded by these polynucleotide sequences. The invention also relates to a novel 110 kDa NTHi outer membrane protein and the polynucleotide that encodes this outer membrane protein. Methods of screening for NTHi infection, and treating and preventing NTHi related disorders are also contemplated.

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Hilliard, OH, United States of America

Robert S Munson, Jr