Other

Yale University

Imperial Cancer Research Technology, Ltd.

Robert S Mann

Spyridon Artavanis-Tsakonas

Grace E Gray

David Ish-Horowicz

Julian Hart Lewis

Robert J Fleming

Anna Mary Myat

Domingos Manuel Henrique

Domingos Manuel Pinto Henrique

Domingos Mp Henrique

Anna M Myat

The present invention relates to nucleotide sequences of Serrate genes, and amino acid sequences of their encoded proteins, as well as derivatives (e.g., fragments) and analogs thereof. In a specific embodiment, the Serrate protein is a human protein. The invention further relates to fragments (and derivatives and analogs thereof) of Serrate which comprise one or more domains of the Serrate protein, including but not limited to the intracellular domain, extracellular domain, DSL domain, cysteine rich domain, transmembrane region, membrane-associated region, or one or more EGF-like repeats of a Serrate protein, or any combination of the foregoing. Antibodies to Serrate, its derivatives and analogs, are additionally provided. Methods of production of the Serrate proteins, derivatives and analogs, e.g., by recombinant means, are also provided. Therapeutic and diagnostic methods and pharmaceutical compositions are provided. In specific examples, isolated Serrate genes, from Drosophila, chick, mouse, Xenopus and human, are provided.

Antibodies to vertebrate serrate proteins and fragments

Protein sequences of serrate gene products

Nucleotide and protein sequences of the serrate gene and methods based

A matched and correlated set of golf club irons is produced by preparing a series of shafts which vary substantially uniformly in flexibility and securing the most flexible shaft to the lowest numbered head in the set, securing the next less flexible shaft to the next higher numbered head, and repeating the process until all the shafts and heads are joined. The shafts are prepared by providing a first group of basic stock shafts of substantially identical stiffness characteristics and cutting off the tip ends in uniformly increasing increments to vary the flexibility. The first group of shafts is connected to heads from the lowest number to one of the middle distance irons. A second group of basic stock shafts having identical stiffness characteristics greater than the first group is similarly prepared and provided for the higher numbered heads. Each successive head is heavier than the preceding head by an increment sufficient to produce a gradual increase in swing weight from the lowest to the highest numbered iron in the set.

Golf club set and method of making

Growing community of inventors

Hamden, CT, United States of America

Robert S Mann