Merck + Co., Inc.

Robert S Hoerrner

Ichiro Shinkai

Leonard M Weinstock

David Askin

Joseph S Amato

Thomas M Liu

Joseph Auerbach

Steven J Cianciosi

Joel J Friedman

John Carolan

Protriptyline can be prepared from 5-dihydrodibenzocycloheptatriene, by deprotonation, followed by reaction at low temperatures with 1,3-bromochloropropane to give the 5-(chloropropyl)-dibenzocycloheptatriene, which is reacted with methylamine in a displacement reaction to give the protriptyline product.

Process for preparing dibenzocycloheptene compounds

A process of reductive amination efficiently yields an HIV protease inhibitor.

Reductive amination process

Anti-ulcer agents having a methylsulfinyl bridge between a substituted pyridine moiety and a substituted benzimidazole moiety are prepared by oxidizing the corresponding compounds, having a methylthio bridge, with magnesium monoperoxyphthalate in a suitable solvent. The reaction may be run in an aromatic hydrocarbon solvent, wherein the product may crystallize out of the reaction solution and may be directly isolated by filtration.

Process for the preparation of antiulcer agents

Growing community of inventors

Scotch Plains, NJ, United States of America

Robert S Hoerrner