Ablative Solutions, Inc.

Topera, Inc.

Stacyc, Inc.

Zipline Medical, Inc.

Johns Hopkins University

Neurolutions, Inc.

Oncosec Medical Incorporated

Rep Concepts, Inc.

Robert Ryan Ragland

Eric Thomas Johnson

Darrin James Kent

Jeff Alan Burke

Andy Edward Denison

Christopher Scott Hayden

David R Fischell

Tim A Fischell

Robert E Fischell

Phillip Charles Burke

Thomas F Kordis

Monibert Narito Gaba

Lawrence Michael Paige

Jamie Richard Beckett

Ruchir Sehra

Kevin Martin Magrini

Amir Belson

Eric Storne

Philip C Burke

Eric Leuthardt

Luke W Clauson

Peter J D'Aquanni

Daniel W Moran

Anthony Nicolas Kalloo

Gerwin Schalk

Mouen A Khashab

Robert H Pierce

Rob Coker

Jean Campbell

Arya Bahrami

Douglas W Brown

Gilbert L Carlson

Thomas Voorhees

David Bundy

Richard J Connolly

Eric Johnson

Eric C Leuthardt

Peter J D'AQUANNI

Electric bicycle frame

A bike includes a frame having a front fork rotatably engaged with a front wheel, a rear fork rotatably engaged with a rear wheel, a handlebar supported for steering the bike, and a drive module configured to drive the rear wheel of the bike when operated selectively with power. The frame includes a down tube extending downward and rearward from the front end of the bike and a drive module enclosure formed at a second end of the down tube and defining a drive module receptacle to receive the drive module. An alignment structure is positioned between the drive module and the inner surface of the drive module enclosure. The drive module is positioned within the drive module receptacle to form an engagement between the alignment structure and the drive module to support a first portion the drive module within the drive module receptacle.

Bike frame having a drive module enclosure

A system for sensing multiple local electric voltages from endocardial surface of a heart, includes: an elongate tubular member having a lumen, a proximal end and a distal end; a plurality of flexible splines; an anchor for securably affixing the proximal portions of the splines, where the anchor is securably affixed within the lumen of the elongate tubular member at the distal end of the elongate tubular member; and a metallic tip for securably affixing the distal portions of the splines.

Basket style cardiac mapping catheter having a flexible electrode assembly for detection of cardiac rhythm disorders

An intravascular catheter for peri-vascular or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. A method can involve injection/infusion of the ablative fluid over an extended time period of at least 10 seconds or with two injections at two different penetration depths to reduce or eliminate patient pain during ablation.

Method for painless renal denervation using a peri-vascular tissue ablation catheter with support structures

An intravascular catheter for peri-vascular and/or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and/or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The system may also include a means to limit and/or adjust the depth of penetration of the ablative fluid into and beyond the tissue of the vessel wall. The catheter may also include structures which provide radial and/or lateral support to the guide tubes so that the guide tubes expand uniformly and maintain their position against the interior surface of the vessel wall as the sharpened injection needles are advanced to penetrate into the vessel wall.

Peri-vascular tissue ablation catheter with support structures

A running bike includes a front fork, a rear fork, a handlebar, and a frame extending between and connecting the front fork and the rear fork. The frame has a top tube and a seat tube coupled to the top tube. A seat is adjustably coupled to the seat tube. A footrest is connected to and supported by the frame, a drivetrain receiving region is defined as an area below the top tube and above the footplate, a drivetrain assembly is positioned within the drivetrain receiving region, and a battery mount selectively receives a battery. The battery mount faces the front wheel at a position between the top tube and the footrest. A side panel is coupled to the frame to enclose the drivetrain assembly within the drivetrain receiving region, and has in side view, a plurality of edges positioned between the top tube and the footrest.

Motorized running cycle

An intravascular catheter for peri-vascular and/or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and/or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The system may also include a means to limit and/or adjust the depth of penetration of the ablative fluid into and beyond the tissue of the vessel wall. The catheter may also include structures which provide radial and/or lateral support to the guide tubes so that the guide tubes expand uniformly and maintain their position against the interior surface of the vessel wall as the sharpened injection needles are advanced to penetrate into the vessel wall. A method can involve injection/infusion of the ablative fluid over an extended time period of at least 10 seconds or with two injections at two different penetration depths to reduce or eliminate patient pain during ablation.

Peri-vascular tissue ablation catheters

An intravascular catheter for peri-vascular and/or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand with open ends around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and/or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The system also includes means to limit and/or adjust the depth of penetration of the ablative fluid into and beyond the tissue of the vessel wall. The preferred embodiment of the catheter includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened injection needles are advanced to penetrate into the vessel wall.

Transvascular methods of treating extravascular tissue

A bike includes a frame elongated in a longitudinal direction, a front fork rotatably engaged with a front wheel at a front end of the bike, a rear fork rotatably engaged with a rear wheel at a rear end of the bike, a handlebar supported for rotation at the front end of the frame for steering the bike, and a drive module configured to drive the rear wheel of the bike when operated selectively with power. The frame includes a down tube extending downward and rearward from the front end of the bike and a drive module enclosure formed at a second end of the down tube. The drive module enclosure defines a drive module receptacle that is open along the longitudinal direction of the bike. The drive module receptacle is sized to receive the drive module along the longitudinal direction of the bike.

Electric bicycle

A running bike that can be operated selectively with and without power. The running bike includes a front fork rotatably engaged with a front wheel, a rear fork rotatably engaged with a rear wheel, the rear fork having an upper portion and a lower portion, and a handlebar rotatably engaged with the front fork for steering the running bike. A frame extends between and connects the front fork and the rear fork. The frame includes a down tube having a first end connected to the front fork and a second end opposite the first end and positioned adjacent the rear fork, a top tube connected to and extending between the down tube and the upper portion of the rear fork, and a drivetrain receiving region defined as an area rearward of the down tube, forward of the rear wheel, and below the top tube.

Convertible motorized running cycle

The present disclosure provides a device and methods for acquiring tissue within a lumen or for closure of bodily openings.

Method and device for tissue acquisition or closure

An adaptive control method for controlling EP pulse parameters during electroporation (EP) of cells or tissue using an EP system includes providing a system for adaptive control to optimize EP pulse parameters including EP pulse parameters, applying voltage and current excitation signals to the cells, obtaining data from the current and voltage measurements, and processing the data to separate the desirable data from the undesirable data, extracting relevant features from the desirable data, applying at least a portion of the relevant features to a trained diagnostic model, estimating EP pulsing parameters based on an outcome of the applied relevant features, where the initialized EP pulsing parameters are based on the trained model and the relevant features, to optimize the EP pulsing parameters, and applying, by the generator, a first EP pulse based on the first pulsing parameters.

Systems and methods for improved tissue-sensing based electroporation

Growing community of inventors

Temecula, CA, United States of America

Robert Ryan Ragland