Other

Genentech, Inc.

The General Hospital Corporation

University of Minnesota

F. Hoffmann-La Roche Ag

Biomet C.v.

Robert Royal Graham

Timothy W Behrens

Teodorica L Bugawan

Brian Yaspan

Amy Dressen

Zhengrong Li

Erich Strauss

Roy Werner Sanders

Cesare Cavallazzi

Edward Mebarak

Marcus Bourda

G Mark Lindsay

David Altshuler

Geoffrey Hom

Michael S O'Donnell

Ward A Ortmann

Howard Shapiro

Tsontcho Ianchulev

The invention provides methods and compositions for treating various degenerative diseases (e.g., AMD) with a factor D inhibitor (e.g., anti-factor D antibody or antigen-binding fragment thereof). Also provided are methods of selecting or identifying patients for treatment with a factor D inhibitor. Methods include the use of prognostic and/or predictive biomarkers.

Compositions and method for treating complement-associated conditions

Compositions for detecting complement factor H (CFH) and complement factor I (CFI) polymorphisms

Methods of identifying, diagnosing, and prognosing lupus, including certain subphenotypes of lupus, are provided, as well as methods of treating lupus, including certain subpopulations of patients. The methods provided are based on a set of alleles associated with systemic lupus erythematosus (SLE) risk loci including BLK, TNIP1, PRDM1, JAZF1, UHRF1BP1, IL10, IFIH1, CFB, CEC16A, IL12B and SH2B3 that contribute to SLE risk. Also provided are methods for identifying effective lupus therapeutic agents and predicting responsiveness to lupus therapeutic agents.

Methods for treating, diagnosing, and monitoring lupus

Methods and materials involved in diagnosing SLE are provided herein. The methods and materials can be used to diagnose SLE and/or assess a mammal's susceptibility to develop SLE, based on the presence or absence of one or more IRF-5 variants.

IRF-5 haplotypes in systemic lupus erythematosus

The present invention may be used as an apparatus and method for extracting oil from a hydrocarbon material bearing formation. A well may be positioned in a formation having hydrocarbon material with a well casing extending into the formation that may have a number of apertures formed in the casing wall adjacent to multiple zones of interest in the formation. A hydrostatic separator may have a specific gravity approximately equal to an oil that may be extracted from the formation and may be positioned and anchored in the well casing above and adjacent to an upper level of said formation. An extraction pipe may be disposed interior to the well casing with a lower end positioned above and adjacent a separator top and may have an upper end attached at a well head. The well head may be in fluid communication with an oil storage unit and in communication with a pressure application apparatus.

Hydrostatic separator apparatus and method

A normally open gas supply safety valve sensitive to earthquake accelerations on x, y and z axes to displace a ball valve restrained by an arcuate groove with edges over which the ball valve rolls onto a seat for positive shut-off, including an abutment to ensure ball movement onto the seat, and including a leveler for installation.

Gas supply safety valve for earthquake protection

A fishing machine mounted on the side rail of a boat for automatically catching and boating fish. A rigid bracket is attached to the boat. The bracket has a base plate pivotally mounted thereon. A stator of a rotary actuator is attached to the base plate with its rotor supporting a hollow elongated fishing pole extending away from the boat to a fishing position over the water adjacent the outer deck periphery of the boat. A self-reciprocating hydraulic cylinder is attached between the bracket and the base plate to provide horizontal oscillational movement to the fishing pole. A fishing line with a fish catching lure at one end positioned below the surface of the water passes through the hollow fishing pole and its other end is attached to the control for the rotary actuator. Whn the weight of a fish is transmitted via the line to the rotary actuator control, the actuator rotor rotates in a manner to elevate the pole tip to a position over the deck of the boat. When the weight of the fish is no longer transmitted to the control, the rotor rotates in the opposite direction until the pole is again in its outboard fishing position. An additional control is provided to vertically oscillate the tip of the pole while in the fishing position in the absence of an attached fish.

Automatic fishing machine

Growing community of inventors

San Francisco, CA, United States of America

Robert Royal Graham