Amo Groningen B.v.

Johnson & Johnson Surgical Vision, Inc.

Robert Rosen

Carmen Canovas Vidal

Hendrik Albert Weeber

Aixa Alarcon Heredia

Franck Emmanuel Gounou

Marrie H Van Der Mooren

Patricia Ann Piers

Dora Sellitri

Mihai State

Sieger Meijer

Huawei Zhao

Theophilus Bogaert

Henk A Weeber

Roy Reints

Christopher Reeves

Robin Zonneveld

Kaccie Y Li

Miguel Faria Ribeiro

Mark Jenkins Sanchez

Bram Koopman

Tjeerd Zuidema

Bart Cannegieter

Chloé Pagot

Johan Le Brun

Julien Adrian

Tanguy Séron-Camps

Yichao Liu

Ariel Zenouda

Mengchan Sun

A method of quantifying the effect of peripheral optical errors on driving includes displaying, on a central portion of a display, a visual representation of a vehicle on a dynamic roadway; intermittently displaying a curve in the dynamic roadway; intermittently displaying, on a peripheral portion of the display, a target object; receiving a signal in response to a participant viewing the target object; determining a reaction time and determining target detection accuracy. Another method includes displaying a participant vehicle and a lead vehicle in front of the participant vehicle on a roadway; signaling an alert when the participant vehicle is outside of a distance range to the lead vehicle; intermittently displaying, on a peripheral portion of the display, a target object; receiving a signal in response to a participant detecting the target; and quantifying the effect of the peripheral optical errors based on reaction time and target detection accuracy.

Driving simulator testing for determining the functional impact of peripheral optical errors

Systems and methods are provided for improving overall vision in patients suffering from a loss of vision in a portion of the retina (e.g., loss of central vision) by providing symmetric or asymmetric optic with aspheric surface which redirects and/or focuses light incident on the eye at oblique angles onto a peripheral retinal location. The intraocular lens can include a redirection element (e.g., a prism, a diffractive element, or an optical component with a decentered GRIN profile) configured to direct incident light along a deflected optical axis and to focus an image at a location on the peripheral retina. Optical properties of the intraocular lens can be configured to improve or reduce peripheral errors at the location on the peripheral retina. One or more surfaces of the intraocular lens can be a toric surface, a higher order aspheric surface, an aspheric Zernike surface or a Biconic Zernike surface to reduce optical errors in an image produced at a peripheral retinal location by light incident at oblique angles.

Intraocular lens that improves overall vision where there is a local loss of retinal function

Intraocular lenses for reducing negative dysphotpsia (ND) are described herein. An example ophthalmic lens can include an optic () with a central optical zone () disposed about the optical axis (OA) and an attenuation optical zone () disposed about the central optical zone (), wherein the attenuation optical zone () is contiguous with the central optical zone (), and wherein optical power of the ophthalmic lens is gradually reduced within the attenuation optical zone ().

Intraocular lenses for reducing negative dysphotopsia

A ring halometer system configured to quantify dysphotopsias in a patient. The system includes a white screen and a first light source configured to emit a glare source from the white screen. The glare source is configured to form a veil of light visible to the patient when the glare source interacts with an optical surface of the eye of the patient. The system also includes a second light source configured to project a light ring with varying luminance concentric with the glare light source on the white screen, and a controller coupled to the second light source configured to adjust a size of the light ring. The system may also include an electronic device configured to determine a level of bothersomeness of the dysphotopsias experienced by the patient based on the size of the light ring.

Ring halometer system and method for quantifying dysphotopsias

Apparatuses, systems and methods for providing improved ophthalmic lenses, particularly intraocular lenses (IOLs), include features for vertex matching distance regions of such lenses. Exemplary ophthalmic lenses can include an optic disposed about an optical axis and having a refractive profile including a region having an add power and a first distance region and a second distance region extending outward from the first distance region and being vertex matched with the first distance region.

Multi-region refractive lenses for vision treatment

Apparatuses, systems and methods for providing improved ophthalmic lenses, particularly intraocular lenses (IOLs), include features for providing improved extended depth of focus lenses. Exemplary ophthalmic lenses can include an optic including a diffractive profile including at least one set of echelettes, each echelette of the set having a different width in r-squared space than any other echelette of the set and the at least one set of echelettes repeating at least once upon the optic.

Achromatic lenses and lenses having diffractive profiles with irregular width for vision treatment

Systems and methods for improving vision of a subject implanted with an intraocular lens (IOL). In some embodiments, a method includes determining at least one photic phenomenon experienced by the subject after implantation of the IOL; and applying a plurality of laser pulses to the IOL, the laser pulses being configured to produce, by refractive index writing on the IOL, a phase shift in the IOL to compensate for the photic phenomenon.

Systems and methods for correcting photic phenomenon from an intraocular lens and using refractive index writing

Systems and methods for improving vision of a subject implanted with an intraocular lens (IOL). In some embodiments, a method includes vergence matching for an intraocular lens (IOL) having an optical profile induced by refractive index writing.

Systems and methods for vergence matching with an optical profile and using refractive index writing

A method of quantifying the effect of peripheral optical errors on patient locomotion includes projecting a pattern on the floor that includes a discrete shapes and empty spaces between the discrete shapes. The method also includes tracking a position of the participant along the pattern as the participant traverses the pattern, and determining foot placement accuracy, utilizing a optical motion capture system and a computer, as the participant walked through the pattern by determining a total area of overlap between the participant's feet and the empty spaces of the pattern. In another embodiment, the method includes arranging obstacles in front of a participant, intermittently displaying a character in front of the participant, determining participant's accuracy in identifying or counting the characters, and determining the participant's step length and foot clearance as the participant steps over the obstacles to quantify the effect of the peripheral optical errors on the participant's locomotion.

System and method for determining the impact of peripheral optical errors on patient locomotion

Systems and methods for improving vision of a subject implanted with an intraocular lens (IOL). In some embodiments, a method includes determining a deviation in position of at least one optical element from a reference line corresponding to alignment of the apex of the cornea, center of the pupil, center of the IOL, and fovea, and/or determining a tilt of at least one of the optical elements relative to the reference line. The method can further include applying a plurality of focused laser pulses to a selected area of the implanted IOL to produce, through refractive index writing, a phase change pattern on the IOL that is configured to compensate for the deviation(s) and/or tilt to improve the foveal vision of the subject.

Systems and methods for improving vision from an intraocular lens in an incorrect position and using refractive index writing

Systems and methods for improving vision of a subject implanted with an intraocular lens (IOL). In some embodiments, a method of treating an ocular disease of a subject having an implanted intraocular lens (IOL) includes determining visual needs of a subject that are associated with an ocular disease of the subject determining a pattern of a plurality of pulses of radiation to apply, by refractive index writing, and applying the plurality of pulses of radiation to the one or more selected areas of the IOL.

Systems and methods for treating ocular disease with an intraocular lens and refractive index writing

Apparatuses, systems and methods for providing improved ophthalmic lenses, particularly intraocular lenses (IOLs), include features for reducing dysphotopsia effects, such as haloes and glare. Exemplary ophthalmic lenses can include an optic including a diffractive achromat configured to direct light to a common focus, with individual zones of the diffractive achromat directing light to the common focus in at least two different diffractive orders utilizing at least two different diffractive powers.

Achromatic lenses with zone order mixing for vision treatment

A psychophysical method, system, and apparatuses to characterize visual symptoms. A method may include presenting one or more stimuli to a patient indicating one or more visual symptoms. The patient may produce one or more responses to the stimuli. A determination of a measure of visual symptoms of the patient may be made utilizing a Bayesian method based on the responses.

Psychophysical method to characterize visual symptoms

Apparatuses, systems and methods for providing improved ophthalmic lenses, particularly intraocular lenses (IOLs), include features for reducing dysphotopsia effects, such as haloes and glare, in extended range of vision lenses. Exemplary ophthalmic lenses can include an optic including a first surface and a second surface each disposed about an optical axis and extending radially outward from the optical axis to an outer periphery of the optic. A diffractive profile including a plurality of echelettes is disposed on the first surface such that no echelette on the first surface repeats between the optical axis and the outer periphery of the optic.

Diffractive lenses for presbyopia treatment

Systems and methods for evaluating ND are described herein. An example method can include constructing a non-sequential (NSC) ray-tracing model of an eye with an ophthalmic lens, and modelling a light source and a detector. The detector can be configured to mimic a retina of the eye. The method can also include computing irradiance data using the light source, the NSC ray-tracing model, and the detector. Irradiance data can be computed for each of a plurality of pupil sizes. The method can further include evaluating ND by analyzing the respective irradiance data for each of the pupil sizes. Also described herein are methods for designing an ophthalmic lens edge that reduces the incidence of ND for a given ophthalmic lens by adjusting the edge thickness and/or the scatter.

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Groningen, Netherlands

Robert Rosen