Rhone-Poulenc Rorer S.a.

Rhone-Poulenc Sante

Robert Rona

Eraclis Statiotis

Pierre Labourt-Ibarre

Michel Deleuil

Manuel Esteban

Luis A Del Rio

Ana Calvo

Francois-Xavier Piot

New formulations of spiramycin suitable for oral administration, particularly for children, comprise spiramycin and potassium acesulfame. These formulations mask the bitterness of spiramycin without adversely affecting the bioavailability or stability of the spiramycin. Preparation by wet granulation followed by dry state mixing is also disclosed.

Pharmaceutical formulations of spiramycin

Oral spiramycin formulations and method for preparing same

Process for the preparation of pearls based on a pharmaceutical active substance exhibiting an indefinite crystallization point. The said active substance is mixed in molten form with a pharmaceutical excipient promoting the solidification of the active substance, the melt is forced to pass through a nozzle which is subjected to a vibration, the pearls formed are allowed to fall in a tower countercurrentwise to a gas, and the pearls formed are collected in the bottom of the tower.

Process for the preparation of medication in the form of pearls

Process for the preparation of pearls based on a pharmaceutical active substance exhibiting an indefinite crystallization point. The said active substance is mixed in molten form which a pharmaceutical excipient promoting the solidification of the active substance, the melt is forced to pass through a nozzle which is subjected to a vibration, the pearls formed are allowed to fall in a tower countercurrentwise to a gas, and the pearls formed are collected in the bottom of the tower.

Process for the preparation of medications in the form of pearls

Growing community of inventors

Saint Germain-en-Laye, France

Robert Rona