Hoechst Aktiengesellschaft

Hoechst Aketiengesellschaft

Robert Rippel

Andreas W Herling

Hans-Jochen Lang

Klaus Weidmann

Hildegard Nimmesgern

Peter Schindler

Manfred Rosner

Horst Hemmerle

Hans-Wolfram Flemming

Roland Utz

Karl-Heinz Scheunemann

Manfred Rukwied

Weidmann, Klaus

Substituted cyclohexane derivatives for the treatment of diseases Esters of cyclohexane derivatives of the formula I ##STR1## in which A--B, R.sup.3, R.sup.4, R.sup.5, Y and Z have the meanings indicated, for use as inhibitors of the glucose-6-phosphatase system of the liver in mammals are described. The compounds are suitable for the production of pharmaceutical preparations.

Substituted cyclohexane derivatives for the treatment of diseases

Process for the preparation of thiophene derivatives and also new dihydrothiophene 1-oxides. Thiophene derivatives having an--optionally substituted--amino group on the thiophene ring are prepared by dehydrogenating dihydrothiophenes, substituted in a manner identical to that of the desired thiophene derivatives, by means of H.sub.2 O.sub.2, the dihydrothiophenes being reacted with H.sub.2 O.sub.2 in a first reaction stage in a neutral medium to give the corresponding sulfoxides, which are then rearranged into the thiophene derivatives by means of acid in the second reaction stage. The dihydrothiophene 1-oxides formed as intermediates in this reaction are new compounds. Like the thiophene derivatives formed from them by rearrangement with acid, they are intermediates, mainly in the sector of plant protection agents and pharmaceuticals.

Process for the preparation of thiophene derivatives and also new

Substituted thienoimidzaole derivatives, processes for their preparation, pharmaceutical preparations containing them and their use as inhibitors of gastric acid secretion. The invention relates to substituted thienoimidazole derivatives of the formula ##STR1## in which A stands for ##STR2## T denotes --S--, --SO-- or --SO.sub.2 --, R.sup.7 denotes a substituted aryloxy or aralkoxy radical and R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.8 have the meanings indicated in the description, processes for their preparation, pharmaceutical preparations containing them and their use as medicaments.

Substituted thienoimidazole derivatives

Substituted thienoimidazole derivatives, a process for the preparation thereof, pharmaceutical compositions containing them, and the use thereof as inhibitors of gastric acid secretion, as gastroprotectives and as medicaments for intestinal inflammations The invention relates to compounds of the formula ##STR1## in which A represents ##STR2## T denotes --S--, --SO-- or --SO.sub.2 --, R.sup.1 to R.sup.10, X, Y and Z have the meanings indicated in the description, to a process for the preparation thereof, to pharmaceutical compositions containing them, and to the use thereof as inhibitors of gastric acid secretion, as gastroprotectives and as medicaments for intestinal inflammations.

Substituted thienoimidazole derivatives, a process for the preparation

Thienoimidazole-toluidines of the formula I ##STR1## in which A represents ##STR2## T denotes --S--, --SO-- or --SO.sub.2 --, and R.sup.1 to R.sup.9 have the meanings stated in the description, and a process for their preparation, pharmaceutical compositions containing them, and their use as inhibitors of gastric acid secretion, are described.

Substituted thienoimidazole-toluidine derivatives as inhibitors of

The invention relates to compounds of the formula ##STR1## in which A represents ##STR2## T denotes --S--, --SO-- or --SO.sub.2 --, and R.sup.1 to R.sup.9 have the meanings given in the description, to a process for their preparation, to pharmaceutical compositions containing them, and to their use as inhibitors of gastric acid secretion.

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Hofheim am Taunus, Germany

Robert Rippel