Warner-lambert Company

Wendstone Chemicals Plc

Rhone-poulenc Chimie

Rhodia Chimie

Almac Sciences (scotland) Limited

Laporte

Almac Sciences Limited

Robert Ramage

Sheila H DeWitt

Carl F Deering

Gilles Raphy

Alasdair Arthur MacDonald

Kenneth Earl Mennen

Graham John Cotton

Sarah Claire Monique Couturier

Beatrice Maltman

Robert Austin Simms McMordie

Graham Cotton

Robert Austin Simms Mcmordie

Alastair Hay

The present invention relates to fluorescent dyes based on acridine derivatives and use of such dyes, for example, in biochemical and/or cell based assays. A preferred feature of some of the dyes described is their long fluorescence lifetimes and their use to label biological molecules.

Fluorescent dyes and uses thereof

A method for the preparation and purification of compounds using a novel support, a tetrabenzo &lsqb;a, c, g, i&rsqb;-fluorene group (Tbf) comprising reacting a building block (A) containing a Tbf group (Tbf-A), with a second building block (B), to afford an intermediate compound (Tbg-A-B) followed by purifying the intermediate compound by adsorption on a carbon support, removing the intermediate compound from the support with a solvent and repeating the previous reactions using the required number of building blocks to synthesize the compounds followed by removal of the Tbf group to afford the desired compounds.

Support for synthesis and purification of compounds

An improved process for the preparation of a cyclic amino acid by a novel synthesis is described where benzonitrile is treated with an alkali metal and an amine under Birch reduction conditions to generate in situ an anionic intermediate which is alkylated with an &agr;-haloacetic acid moiety which is subsequently converted to the desired product, as well as valuable intermediates used in the process.

Process for preparing a cyclic amino acid anticonvulsant compound

Protective group, compound protected by said group and device for grafting the protective group on the compound to protect it

A method for the preparation and purification of compounds using a novel support, a tetrabenzo[a,c,g,i]fluorene group (Tbf) comprising reacting a building block (A) containing a Tbf group (Tbf-A), with a second building block (B), to afford an intermediate compound (Tbg-A-B) followed by purifying the intermediate compound by adsorption on a carbon support, removing the intermediate compound from the support with a solvent and repeating the previous reactions using the required number of building blocks to synthesize the compounds followed by removal of the Tbf group to afford the desired compounds.

Method and means for oligonucleotide separation

The protective group having the following formula (I):

Protected compound comprising a protective group removably attached to a

A novel class of protecting compounds, particularly for amino acids, is based on 2,2 di nitrophenyl ethan- groups, particularly the groups wherein the nitro is in the para position. The ethyl group may be substituted, e.g. by an alkyl group, in the l- position. Preferred compounds include the alcohol or halide which are suitable for protecting acid functional groups, and esters, including activated and substituted esters, particularly the succinimidyl ester, for protecting amine groups. The invention includes methods of manufacture and use, together with protected amino acids.

Chemical compounds

A class of novel chemical compounds comprising derivatives of 2,2,5,7,8-pentamethylchroman-6-sulphonyl and having the structural formula ##STR1## wherein X is selected from halogen and other groups having acidic functionality. We prefer that the X-group be chlorine. The said compounds are made by the sulphonation of 2,2,5,7,8-pentamethylchroman, preferably using chlorosulphonic acid. The primary utility of the compounds of the present invention is in the protection of functional groups in organic synthesis and more particularly in the protection of basic functional amino groups, such as amidines and guanidines. The invention also provides a method of making the protecting group and a protected amino acid.

Amino acids protected with 6-sulfonyl chromans

6-sulfonyl chromans

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Edinburgh, United Kingdom

Robert Ramage