Elan Pharmaceuticals, Inc.

Robert R Luther

David J Ellis

Dawn McGuire

Vandana Mathur

S Scott Bowersox

Theresa Gadbois

Mark Raymond Pettus

Transdermal administration of fenoldopam, both the racemic mixture and the active R-fenoldopam enantiomer, is described. Also described are transdermal patches for therapeutically effective transdermal administration of racemic fenoldopam and its active R-fenoldopam enantiomer to a subject in need of treatment for impaired renal function or hypertension.

Transdermal administration of fenoldopam

A improved method of treating pain is disclosed. The method includes administering to a subject an N-type voltage-sensitive calcium channel blocking omega conopeptide which is characterized by its ability to (a) inhibit electrically stimulated contraction of the guinea pig ileum, and (b) bind selectively to omega conopeptide MVIIA binding sites present in neuronal tissue. The method includes administering the omega conopeptide epidurally, preferably so that the compound is in prolonged or sustained contact with the epidural region.

Epidural method of producing analgesia

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Reno, NV, United States of America

Robert R Luther