University of South Florida

The United States Government as Represented by the Department of Veterans Affairs

University of Rochester

University of Florida Research Foundation Inc

Robert Pleasants Sparks

Wayne Charles Guida

Niketa A Patel

Denise Ratzlaff Cooper

Rekha S Patel

Ryan Adam Kirchoffer

Janet Lindsay DeHoff-Sparks

Provided herein are formulations that can contain an effective amount of a PKCδ inhibitor. Also provided herein are methods of inhibiting a PKCδ in a subject in need thereof, that can include the step of administering an effective amount of a compound that is capable of inhibiting a PKCδ.

PKC-Delta-I inhibitor formulations and uses thereof

Provided herein are formulations that can contain an effective amount of a PKC&#x3b4; inhibitor. Also provided herein are methods of inhibiting a PKC&#x3b4; in a subject in need thereof, that can include the step of administering an effective amount of a compound that is capable of inhibiting a PKC&#x3b4;.

PKC-delta-I inhibitor formulations and uses thereof

Various scaffolds of small molecules capable of binding to the active site of sortilin are identified by in silico methods. These scaffolds include norbornene anhydride amino acid adducts and 2-substituted 3-oxo-1,2,3,4-tetrahydro-2-quinoxalines. These sortilin ligands increase the uptake of glucose in 3T3L1 cells and can be employed in compositions to increase uptake of glucose for the treatment of diabetic patents.

Sortilin-binding small molecules for increasing glucose uptake

Disclosed herein are compositions and methods for transitioning or converting a white adipocyte to a beige adipocyte. The compositions and methods may be used in the treatment of obesity. In some embodiments, the compositions include a compound selected from DC677 and DC761.

Compositions and methods for white to beige adipogenesis

Provided herein are compounds and formulations thereof that can be capable of binding to sortilin or an analogue thereof. Also provided herein are methods of administering the compounds and formulation provided herein to a subject in need thereof.

Sortilin binding compounds, formulations, and uses thereof

Provided herein are compounds and formulations thereof that can be capable of binding to sortilin or an analog thereof. Also provided herein are methods of administering the compounds and formulation provided herein to a subject in need thereof.

Growing community of inventors

Urbana, IL, United States of America

Robert Pleasants Sparks