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University of Iowa Research Foundation

Behavioral Diagnostics, LLC

Philibert, Robert

Robert Philibert

Anup Madan

Meeshanthini Dogan

Edward I Ginns

Lynn Delisi

Methods and compositions are provided for detecting a predisposition for cardiovascular disease in an individual.

Compositions and methods for detecting predisposition to cardiovascular disease

The present invention provides screening kits, compositions, and diagnostic methods for determining whether a subject has a predisposition to, or likelihood of having, a substance use disorder by determining a nucleic acid methylation profile from a biological sample from the subject, wherein a given profile indicates that the subject has a predisposition to a substance use disorder.

Compositions and methods for detecting predisposition to a substance use disorder

Nucleic acid sequences within the q13 region of the X chromosome having polymorphisms associated with neuropsychiatric disorders and associated conditions are disclosed herein. One polymorphism occurs within the coding region of the HOPA gene and introduces a four amino acid insertion into a putative OPA domain, a domain which has been shown to be involved in tissue specific expression. Compositions including nucleic acids having these polymorphisms and antibodies to polymorphic regions within proteins encoded in the PCTG4 region are provided. Methods of using the information and nucleic acid sequences disclosed herein for the diagnosis and assessment of pathologies associated with neuropsychiatric disorders and associated conditions are also provided.

Identification of polymorphisms in the PCTG4 region of Xq13

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Iowa City, IA, United States of America

Robert Philibert