Ineos Acrylics UK Limited

Imperial Chemical Industries Limited

Robert Paul Tooze

Jamie Michael Thorpe

Graham Ronald Eastham

Peter Gerald Edwards

Richard Anthony Campbell

Paul David Newman

Keith Whiston

Xiao Lan Wang

A method of manufacturing a compound of general formula (R &mdash;C) P&mdash;L &mdash;X&mdash;L &mdash;P&mdash;(C&mdash;R ) , in which each R is independently a pendant, optionally substituted, organic group through which the group is linked to tertiary carbon atom C; L , L are independently a linking group selected from an optionally substituted lower alkylene chain connecting the respective phosphorus atom to the group X and X is a bridging group comprising an optionally substituted aryl moiety to which the phosphorus atoms are linked on available adjacent carbon atoms, comprises: i) reacting together a compound of formula H&mdash;L &mdash;X&mdash;L &mdash;H with an organometallic compound to form an intermediate compound of formula M&mdash;L &mdash;X&mdash;L &mdash;M, where M is an alkali metal atom; ii) reacting said intermediate compound with a compound of formula (R &mdash;C) P&mdash;A, where A is a halogen atom, to form said compound of general formula (R &mdash;C) P&mdash;L &mdash;X&mdash;L &mdash;P&mdash;(C&mdash;R ) , M is preferably lithium, potassium or sodium and the intermediate compound may be isolated or not. The reaction (i) may advantageously be carried out in the presence of a complexing agent such as tetramethyethylenediamine.

Process for the preparation of bisphosphines

A catalyst system capable of catalyzing the carbonylation of ethylene and a process which uses such a system wherein the catalyst system is obtainable by combining a metal of Group VIII, e.g., palladium, or a compound thereof and a bidentate phosphine, e.g. bis(di-t-butyl phospino)-o-xylene, according to the equation C H &plus;CO&plus;ROH&rarr;C H CO R,.

Process for the carbonylation of ethylene and catalyst system for use therein

A method of preparing a compound (I) of general formula (R &mdash;C) P&mdash;L &mdash;X&mdash;L &mdash;P&mdash;(C&mdash;R ) , in which R is independently a pendant, optionally substituted, organic group through which the group is linked to tertiary carbon atoms C; L and L are independently, a linking group selected from an optionally substituted lower alkylene chain connecting the respective phosphorous atom to the group X, and X is a bridging group comprising an optionally substituted aryl moiety to which the phosphorous atoms are linked on available adjacent carbon atoms; comprising: (i) reacting together a compound (II) of formula A&mdash;L &mdash;X&mdash;L &mdash;A, in which A is a halogen atom, with a metal M in a suitable solvent or form an intermediate compound (III) of formula: A&mdash;M&mdash;L &mdash;X&mdash;L &mdash;M&mdash;A; (ii) reacting said intermediate compound (III) with a compound (IV) of formula: (R &mdash;C) P&mdash;A , wherein A is a halogen atom which may be the same as or different from A, to form said compound (I).

Method of manufacturing phosphine compound

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Cleveland, United Kingdom

Robert Paul Tooze