Shire Biochem, Inc.

Shire Holdings Ag

Shire Biopharmaceuticals Holdings Ireland Limited

Robert Paul Haslam

Josephine Christine Ferdinando

Laura Anna Trespidi

Josesphine Christine Ferdinando

This invention relates to a chewable lanthanum formulation comprising a pharmaceutically effective amount of a lanthanum compound; and at least one chewable pharmaceutically acceptable excipient. This invention also relates to a pharmaceutical formulation in a tablet or in a powder comprising a pharmaceutically effective amount of a lanthanum compound produced by a process which comprises the steps of: a) powder blending the lanthanum compound and at least one pharmaceutically acceptable excipient in a mixer to form a mixture; or b) powder blending the lanthanum compound and excipients, compressing the resulting combination into a slug material or roller compacting the resulting combination into a strand material, and milling the prepared material into a free flowing mixture; and c) compressing the resulting mixture into a tablet or filing up the resulting mixture in a appropriate container.

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Pewsey, United Kingdom

Robert Paul Haslam