Roche Palo Alto LLC

Catalytica Pharmaceuticals, Inc.

Robert Patrick Farrell

Keshab Sarma

Stephen Matthew Lynch

Terrence Joseph Connolly

Eric Roy Humphreys

Joseph Arthur Miller

A method comprising: with vitride, to form an aminopropyl indole compound of formula i wherein m, Ar, Rand Rare as defined herein. The compounds prepared by the method of the invention are useful as monoamine reuptake inhibitors useful for treatment of CNS indications.

Methods for synthesis of 3-amino-1-arylpropyl indoles

The present invention provides a process for preparing biaryl compounds comprising reacting an arylmetal reagent selected from arylmagnesium reagents and aryllithium reagents with an arylhalide in the presence of a catalyst system comprising a catalyst selected from nickel catalysts and palladium catalysts and a cocatalyst selected from zinc cocatalysts and cadmium cocatalysts. The present invention specifically provides a process for the preparation of 2-(4'-methylphenyl)benzonitrile comprising reacting a 4-methylphenylmagnesium reagent with a 2-halobenzonitrile in the presence of a catalyst system comprising a catalyst selected from nickel catalysts and palladium catalysts and a zinc cocatalyst.

Process for preparing biaryl compounds

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Mountain View, CA, United States of America

Robert Patrick Farrell