Bristol-myers Squibb Compnay

Domantis Limited

Robert P Rehfuss

Aaron Paul Yamniuk

Suzanne J Suchard

Steven G Nadler

Steven Grant

James William Bryson

Olga Ignatovich

James K Tamura

Anish Suri

Philip Drew

Laura Price

Jacques Y Roberge

Timur Gungor

Timothy F Herpin

R Michael Lawrence

Michael A Poss

Jennifer X Qiao

Tammy C Wang

Charles G Clark

George C Morton

Patrick Y S Lam

Rejean Ruel

Carl Thibeault

Hannguang J Chao

Alexandre L'Heureux

Huji Tuerdi

Gilles Bouthillier

Yalei Liu

Dora M Schnur

Michael R Lawrence

Patrick YS Lam

Timothy Herpin

Jacques Yves Roberge

Alexandre L L'HEUREUX

Antibody polypeptides that specifically bind human CD40L are provided. The antibody polypeptides do not activate platelets. The antibody polypeptides are useful in the treatment of diseases involving CD40L activation, such as graft-related diseases and autoimmune diseases. The antibody polypeptides may be domain antibodies (dAbs) comprising a single Vor Vdomain. The half-life of the antibody polypeptides may be increased by modifying the antibody polypeptides to be dual specific reagents that can also bind human serum albumin (HSA) or another antigen.

Antibody polypeptides that antagonize CD40L

Methods of treating immune diseases by administering antibody polypeptides that specifically bind CD40L

Nucleic acids encoding antibody polypeptides that antagonize CD40L

The present invention provides novel amino-benzazoles and analogues thereof, which are selective inhibitors of the human P2Yreceptor. The invention also provides for various pharmaceutical compositions of the same and methods for treating diseases responsive to modulation of P2Yreceptor activity.

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The present invention provides novel pyridyl or phenyl ureas and analogues thereof, which are selective inhibitors of the human P2Yreceptor. The invention also provides for various pharmaceutical compositions of the same and methods for treating diseases responsive to modulation of P2Yreceptor activity.

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North Wales, PA, United States of America

Robert P Rehfuss