Astellas Institute for Regenerative Medicine

Advanced Cell Technology, Inc.

Ocata Therapeutics, Inc.

Biohybrid Technologies LLC

Cornell Research Foundation Inc.

Biohybrio Technologies LLC

Advance Cell Technology, Inc.

Robert P Lanza

Irina V Klimanskaya

Shi-Jiang Lu

Young Gie Chung

Qiang Feng

William L Chick

Erin Anne Kimbrel

Michael D West

Jianlin Chu

Nicholas Arthur Kouris

Wei Wang

Willem M Kuhtreiber

Jose Cibelli

Kathryn L McCabe

Shahin Rafii

Jay M Edelberg

Roger Gay

Mun K Hong

Dawn M Ecker

Joanne P Marsh

John Ringeling

Young Chung

Methods are provided for the production of photoreceptor cells and photoreceptor progenitor cells from pluripotent stem cells. Additionally provided are compositions of photoreceptor cells and photoreceptor progenitor cells, as well as methods for the therapeutic use thereof. Exemplary methods may produce substantially pure cultures of photoreceptor cells and/or photoreceptor progenitor cells.

Photoreceptors and photoreceptor progenitors produced from pluripotent stem cells

The present invention generally relates to novel preparations of mesenchymal stromal cells (MSCs) derived from hemangioblasts, methods for obtaining such MSCs, and methods of treating a pathology using such MSCs. The methods of the present invention produce substantial numbers of MSCs having a potency-retaining youthful phenotype, which are useful in the treatment of pathologies.

Mesenchymal stromal cells and uses related thereto

The present invention relates to methods of generating and expanding hitman embryonic stem cell derived mesenchymal-like stem/stromal cells. These hES-MSCs are characterized at least in part by the low level of expression of IL-6. These cells are useful for the prevention and treatment of T cell related autoimmune disease, especially multiple sclerosis, as well as for delivering agents across the blood-brain barrier and the blood-spinal cord barrier. Also provided is a method of selecting clinical grade hES-MSC and a method of modifying MSC to produced a MSC with specific biomarker profile. The modified MSC are useful for treatment of various diseases.

Mesenchymal-like stem cells derived from human embryonic stem cells, methods and uses thereof

Methods for production of platelets from pluripotent stem cells, such as human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) are provided. These methods may be performed without forming embryoid bodies or clusters of pluripotent stem cells, and may be performed without the use of stromal inducer cells. Additionally, the yield and/or purity can be greater than has been reported for prior methods of producing platelets from pluripotent stem cells. Also provided are compositions and pharmaceutical preparations comprising platelets, preferably produced from pluripotent stem cells.

Methods for production of human hemogenic endothelial cells from pluripotent stem cells and compositions thereof

Methods for production of platelets from pluripotent stem cells and compositions thereof

This disclosure generally relates to cell-based therapies for treatment of visual disorders, including disorders of the cornea. Methods are exemplified for directed differentiation of corneal cells from stem cells. Compositions of corneal endothelial cells and uses thereof are also provided. Exemplary compositions exhibit improved cell density and/or more 'youthful' gene expression relative to cells obtained from donated tissue.

Corneal endothelial cells with increased cell density and compositions thereof

Methods of generating and expanding human hemangio-colony forming cells in vitro and methods of expanding and using such cells are disclosed. The methods permit the production of large numbers of hemangio-colony forming cells as well as derivative cells, such as hematopoietic and endothelial cells. The cells obtained by the methods disclosed may be used for a variety of research, clinical, and therapeutic applications.

Hemangio-colony forming cells

Methods are provided for the production of photoreceptor cells and photoreceptor progenitor cells from pluripotent stem cells. Additionally provided are compositions of photoreceptor cells and photoreceptor cells, as well as methods for the therapeutic use thereof. Exemplary methods may produce substantially pure cultures of photoreceptor cells and/or photoreceptor cells.

The present invention relates generally to the field of somatic cell nuclear transfer (SCNT) and to the creation of cloned animals and cells. The disclosure relates to a method of cloning a mammal, obtaining pluripotent cells such as embryonic stem cells, or for reprogramming a mammalian cell using an oocyte and a fertilized embryo.

Method of producing a differentiated mammalian cell comprising culturing a single mammalian blastomere

This present invention provides novel methods for deriving embryonic stem cells and embryo-derived cells from an embryo without requiring destruction of the embryo. The invention further provides cells and cell lines derived without embryo destruction, and the use of the cells for therapeutic and research purposes. It also relates to novel methods of establishing and storing an autologous stem cell line prior to implantation of an embryo, e.g., in conjunction with reproductive therapies such as IVF.

Derivation of embryonic stem cells and embryo-derived cells

Growing community of inventors

Clinton, MA, United States of America

Robert P Lanza