Miles Inc.

Bayer Corporation

Other

Miles Laboratories, Inc.

Siemens Healthcare Diagnostics Gmbh

Robert P Hatch

Steven C Charlton

Michael J Pugia

Robert T Buckler

James P Albarella

David L Garling

Nan-Horng Lin

Meitak Teresa Yip

Paul R Hemmes

Scott Ruetten

Robert J Carrico

Klaus Wehling

Joel M Blatt

Jurgen Kocher

Marilyn J Radtke

William L Patterson

N-H Lin

Manju Basu

Devices, apparatus, and methods of using a modified scalpel tool that is removable from a polyurethane mated sheath for use in carpal tunnel surgeries and the like. The modified scalpel tool has an elongated stem with a flat blade at the distal end and an elongated handle at the proximal end. The sheath has a cavity for allowing the elongated blade to be inserted therein, two slots to receive two metal studs and a handle at its proximal end. The flat blade tool when combined (mated) with the polyurethane sheath produces a stable configuration that allows motion in only one rotational plane and with an arc of 90-95 degrees.

Modified surgical scalpel with polyurethane mated sheath: for ultrasound assisted carpal tunnel surgeries

Devices, apparatus, and methods of using a modified scalpel tool that is removable from a polyurethane mated sheath for use in carpal tunnel surgeries and the like. The modified scalpel tool has an elongated stem with a flat blade at the distal end and an elongated handle at the proximal end. The sheath has a cavity for allowing the elongated blade to be inserted therein, two slots to receive two metal studs and a handle at its proximal end. The flat blade tool-polyurethane when combined (mated) produces a stable configuration that allows motion in only one rotational plane and with an arc of 90-95 degrees.

Modified surgical scalpel with polyurethane mated sheath for ultrasound assisted carpal tunnel surgery

A method of detecting creatinine in body fluids using an indicator which produces a fluorescent response when oxidized in the presence of a copper/creatinine complex. A preferred indicator is 4-(1-methylhydrazino)-7-nitro benzooxadiazole (MNBDH).

Fluorescent creatinine assay

Disclosed is a method for the immobilization of an analyte such as deoxypyridinium (DPD) onto a solid support. The method involves binding an antigen-amino acid-deoxypyridinium complex to the support via an anti-antigen binding partner located in a capture zone of the solid support. Preferably, the support is nitrocellulose and the antigen has the fluorescein structure.

Method and device for the detection of analyte in a fluid test sample

Disclosed is an improvement to the technique for immobilizing an analyte onto a solid surface for use in a competitive immunoassay. The improvement involves immobilizing the analyte on the solid surface by reacting the analyte or derivative thereof with polyethylene glycol which has been functionalized with a group which is reactive with the analyte contacting the resulting conjugate with the solid surface to thereby immobilize the analyte.

Method and device for the detection of analyte in a fluid sample

Disclosed is a method for the chemical synthesis of deoxypyridinoline (DPD). The synthesis involves the preparation of a protected 3-hydroxypyridinium starting with a N.alpha.-protected lysine and a 5,6-epoxy-2-N-protected-O-protected-(2S)-2-aminohexanoate with subsequent deprotection to provide the desired DPD.

Method for the synthesis of deoxypyridinoline

Test devices are disclosed which are useful for determining glucose or occult blood comprising a carrier matrix, glucose oxidase, an indicator system and a glucose derivative that upon addition of water hydrolizes to produce glucose.

Test devices for determination of glucose

The present invention involves the use of certain indole sulfonates in a test control method for the Ehrlich reagent used in diagnostic tests for urobilinogen. The indole sulfonates exhibit unique solubility characteristics which facilitate their application to dry carrier matrixes with subsequent rehydration during their use in the test control method.

Device for validating urobilinogen test devices

2-Benzothiazolyl tetrazolium salt compounds have been found to be characterized by a reflectance spectrum exhibiting an extended plateau above about 600-650 nm. Such compounds are useful as chromogenic indicators for reducing substances such as NADH. The reflectance plateau confers improved accuracy to analytical assays, particularly for the determination of analytes of medical diagnostic significance, in which a colorimetric response on a reagent carrier matrix is measured by reflectance.

2-benzothiazolyl tetrazolium salt indicators

Disclosed are sulfonate and phosphonate salts of tetrazolium compounds whose enhanced solubility in various solvents renders them particularly suitable for use as redox indicators in dry reagent, diagnostic test systems.

Use of specific counteranions to modify the solubility of tetrazolium

The present invention relates to a chromogenic benzoisothiazolone polymer derivative for measuring the presence or appearance of thiols in an aqueous system.

Chromogenic thiol indicating benzoisothiazolone compounds

A process for measuring the presence or appearance of thiols in aqueous system, the process involving contacting the aqueous system with a chromogenic thiol indicating benzoisothiazolone derivative and then observing chromophoric changes due to thiol mediated reduction of the benzoisothiazolone derivative wherein the changes are proportional to the amount or rate of appearance of the thiols in the aqueous system.

Process for determining thiols using chromogenic benzoisothiazolone

Newly synthesized chromogenic thiol-indicating benzoisothiazolone derivatives having the structure: ##STR1## where R.sup.1, R.sup.2 and R.sup.3 are as defined in the specification, are useful in the detection of thiols, particularly in an aqueous system. This process comprises contacting the aqueous system with a chromogenic thiol-indicating benzoisothiazolone derivative as described herein. Chromophoric changes due to thiol-mediated reduction of the benzothiazolone derivative then occur. Such changes can be in a solution or on an indicator surface in contact or having been in contact with the aqueous system. The chromophoric changes, due to a bathochromic shift in characteristic light absorption upon reduction of the benzoisothiazolone derivative, are proportional to the amount or rate of appearance of thiols in the aqueous system.

Chromogenic thiol indicators based on an isobenzothiazolone ring system

Newly synthesized chromogenic thiol-indicating benzoisthiazolone derivatives having the structure: ##STR1## where R.sup.1, R.sup.2 and R.sup.3 are as defined in the specification, are useful in the detection of thiols, particularly in an aqueous system. This process comprises contacting the aqueous system with a chromogenic thiol-indicating benzoisothiazolone derivative as described herein. Chromophoric changes due to thiol-mediated reduction of the benzothiazolone derivative then occur. Such changes can be in a solution or on an indicator surface in contact or having been in contact with the aqueous system. The chromophoric changes, due to a bathochromic shift in characteristics light absorption upon reduction of the benzoisothiazolone derivative, are proportional to the amount or rate of appearance of thiols in the aqueous system.

General classes of 2-thiazolyl tetrazolium salt compounds have been found to be characterized by a reflectance spectrum exhibiting an extended plateau above about 600-650 nm. Such compounds are useful as chromogenic indicators for reducing substances such as NADH. The reflectance plateau confers improved accuracy to analytical assays, particularly for the determination of analytes of medical diagnostic significance, in which a colorimetric response on a reagent carrier matrix is measured by reflectance.

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Elkhart, IN, United States of America

Robert P Hatch