Merck + Co., Inc.

Robert P Borris

Deborah L Zink

Otto D Hensens

Leeyuan Huang

Louis Kaplan

Yiu-kuen T Lam

Linda S Wicker

Lawrence R Koupal

Kevin M Byrne

Richard W Burg

Sagrario Mochales

Livia Kelemen

Described is a new immunosuppressant, L-687,819, a C-31 demethylated derivative of L-683,795 (FK-523), produced under fermentation conditions utilizing the new mutant microorganism, Streptomyces hygroscopicus subsp. ascomyceticus (Merck Culture Collection MA 6646) ATCC No. 53855, being a blocked mutant of Streptomyces hygroscopicus subsp. ascomyceticus (MA 6475) ATCC No. 14891. The macrolide immunosuppressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.

Microbial immunoregulant

An alkyl indole of the formula: ##STR1## is a useful antimigraine agent.

Antimigraine alkyl indole

The compounds of Formula I are produced by the aerobic fermentation of a fungus of the genus GLIOCLADIUM, ATCC No. 20826. ##STR1## The compounds of Formula I are inhibitors of testosterone 5.alpha.-reductase and are useful in the treatment and prevention of acne, seborrhea, female hirsutism and benign prostatic hypertrophy.

Sterol inhibitors of testosterone 5.alpha.-reductase

Growing community of inventors

Glen Gardner, NJ, United States of America

Robert P Borris