Other

University of Texas System

Robert P Barnes

Helen H Hobbs

Bei Shan

Thomas A Myers

Hui Tian

Jonathan C Cohen

Christine K Garcia

The present invention provides nucleic acids encoding a novel ABC family cholesterol transporter, ABCG8. The herein-disclosed sequences can be used for any of a number of purposes, including for the diagnosis and treatment of cholesterol-associated disorders, including sitosterolemia, and for the identification of molecules that associate with and/or modulate the activity of ABCG8.

ABCG8 vectors, host cells, and method of making

Low density lipoprotein receptor (LDRL) adaptin is a novel, key component of human cholesterol regulation, which provides a target for rational drug design and screening, therapeutic intervention, and diagnosis. Disclosed reagents include a variety of LDLR adaptin and LDLR adaptin PTB and CC domain compositions, including in vitro compositions comprising a natural human LDLR adaptin PTB domain and a ligand such as an NPXY (SEQ ID NO:7) peptide. These LDLR adaptin reagents are used, inter alia, in rational drug screening methods. The invention also provides polynucleotides encoding the subject LDLR adaptin polypeptides, including natural coding sequences, which may be used as probes or primers for detecting or amplifying LDLR adaptin genes and transcripts.

Drug screen for identifying an agent that modulates low density lipoprotein receptor adaptin-ligand binding

There is disclosed well drilling apparatus which includes a mast pivotally mounted on a base so that it may be tilted about a horizontal axis in order to drill a well at a slant with respect to the vertical, a laydown device at the front side of the mast for use in moving joints of drill pipe to and from the mast, during drilling of the well or on completion of the drilling, and a tower and setback in which stands of drill pipe may be racked, together with a frame extending between the mast and tower to facilitate transfer of the stands of drill pipe between the tower and the mast during tripping of the drill string--i.e., as it is raised from the well, to permit repair or replacement of the drill bit, and then lowered back into the well to resume drilling.

Well drilling apparatus

Growing community of inventors

Corpus Christi, TX, United States of America

Robert P Barnes