University of Texas System

Dispersol Technologies, LLC

Epicept Corporation

Delrx Pharmaceutical Corporation

Rein Therapeutics, Inc.

Other

Integrico Composites, Inc.

Austinpx, LLC

Robert O Williams, Iii

Keith P Johnston

Alan B Watts

Joshua Engstrom

Dave A Miller

Jason T McConville

James William McGinity

True L Rogers

Chris Brough

James C DiNunzio

Robert Talbert

Jay I Peters

Jasmine Rowe

Timothy J Young

Prapasri Sinswat

Feng Zhang

John Joseph Koleng, Jr

Randall Eugene McCoy

Miles Augustus Libbey, Iii

Christopher John Tucker

Eric Van Oort

Hugh D Smyth

Hugh D C Smyth

James E Hitt

Brian D Scherzer

Ali Karimi Vajargah

Dale Christensen

David A Hayes

Besmir B Hoxha

Silvia Ferrati

Sawittree Sahakijpijarn

Zachary N Warnken

Yajie Zhang

Ian B Gillespie

Paula C Garcia

Nicholas S Beck

David S Burgess

Xiaoxia Chen

Yang Lu

Gavril W Pasternak

Steven Idell

Sreerama Shetty

Zhengrong Cui

Yuri Kolesnikov

Matthew J Herpin

Melisa K Barron

Zhongshui Yu

Jiahui Hu

Jle Liu

Xinran Li

James W Mcginity

Miguel Orlando Jara Gonzalez

Hyo-Jong Seo

Ashlee D Brunaugh

Siyuan Huang

Abbe Miller

Jasmine Tam

Compositions and methods of preparing amorphous drug formulations through hot melt extrusion which result in decreased decomposition of the desired drug are provided herein. Also provided are methods and compositions which further comprise a pharmaceutically acceptable thermoplastic polymer. In some embodiments, these compositions comprise a therapeutically active agent which is only sparingly soluble in water.

Methods of preparing extrudates

Provided herein are compositions comprising caveolin-1 (Cav-1) peptides. Further provided are methods of using the Cav-1 peptides for the treatment of lung infections or acute or chronic lung injury, particularly lung fibrosis.

Dry powder formulation of caveolin-1 peptides and methods of use thereof

The present invention includes compositions and methods for treating and delivering medicinal formulations using an inhaler. The composition includes a space filled flocculated suspension having one or more flocculated particles of one or more active agents and a hydrofluoroalkane propellant. A portion of the one or more flocculated particles is templated by the formation of hydrofluoroalkane droplets upon atomization and the templated floc compacts upon the evaporation of the hydrofluoroalkane propellant to form a porous particle for deep lung delivery.

Templated open flocs of anisotropic particles for enhanced pulmonary delivery

The present invention includes compositions and methods for making and using a rapid dissolving, high potency, substantially amorphous nanostructured aggregate for pulmonary delivery of tacrolimus and a stabilizer matrix comprising, optionally, a polymeric or non-polymeric surfactant, a polymeric or non-polymeric saccharide or both, wherein the aggregate comprises a surface area greater than 5 m/g as measured by BET analysis and exhibiting supersaturation for at least 0.5 hours when 11-15-times the aqueous crystalline solubility of tacrolimus is added to simulated lung fluid.

Methods for making compositions for pulmonary administration

Devices and methods for nasal administration of a pharmaceutical composition. In certain embodiments, the devices comprises a reservoir, a conduit in fluid communication with the reservoir, and an anatomic positioning device configured to position the conduit in a nasal cavity of a user. Particular embodiments include an actuator configured to transfer the pharmaceutical composition from the reservoir to the conduit and emit the pharmaceutical composition from the conduit.

Compositions and devices to administer pharmaceutical compositions nasally

The present disclosure provides pharmaceutical compositions of niclosamide that may be administered either orally or by inhalation. These compositions may allow the achievement of a therapeutically effective dose of niclosamide to the lungs or the gastrointestinal tract. These compositions may be used to treat one or more diseases or disorders such as a viral infection or cancer.

Pharmaceutical compositions of niclosamide

Compositions and methods of making brittle-matrix particles through blister pack freezing

Compositions and methods for making a pharmaceutical dosage form include making a pharmaceutical composition that includes one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients by thermokinetic compounding into a composite. Compositions and methods of preprocessing a composite comprising one or more APIs with one or more excipients include thermokinetic compounding, comprising thermokinetic processing the APIs with the excipients into a composite, wherein the composite can be further processed by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.

Thermo-kinetic mixing for pharmaceutical applications

Disclosed herein are compositions and methods for reducing fluid loss in a well bore, methods for wellbore strengthening and increasing the integrity of the borehole of an oil or gas well. Also disclosed are methods for artificially increasing the temperature of a subsurface formation in the wellbore to increase the apparent wellbore strength. The mechanism for accomplishing this revolves around increasing fracture propagation pressure by actively manipulating thermal wellbore stresses.

Methods for increasing wellbore strength

The present invention includes compositions and methods for preparing micron-sized or submicron-sized particles by dissolving a water soluble effective ingredient in one or more solvents; spraying or dripping droplets solvent such that the effective ingredient is exposed to a vapor-liquid interface of less than 50, 100, 150, 200, 250, 200, 400 or 500 cmarea/volume to, e.g., increase protein stability; and contacting the droplet with a freezing surface that has a temperature differential of at least 30&#xb0; C. between the droplet and the surface, wherein the surface freezes the droplet into a thin film with a thickness of less than 500 micrometers and a surface area to volume between 25 to 500 cm.

Formation of stable submicron peptide or protein particles by thin film freezing

Described herein are dry vaccine compositions and methods of freezing aluminum-containing vaccines such that when converted into a dried powder, the dry vaccine can be readily reconstituted to form a stable liquid vaccine without significant loss of activity.

Dry solid aluminum adjuvant-containing vaccines and related methods thereof

Enhanced delivery of immunosuppressive drug compositions for pulmonary delivery

Growing community of inventors

Austin, TX, United States of America

Robert O Williams, Iii