Washington University

Robert O Heuckeroth

Steven P Adams

Jeffrey I Gordon

George W Gokel

Novel oxy- and thio-substituted fatty acid analog substrates of myristoylating enzymes are provided which contain an oxygen or sulfur in place of a methylene group in a carbon position from 4 to 13 in the fatty acid chain of a C.sub.13 -C.sub.14 fatty acid or alkyl ester thereof.

Fatty acid analog enzyme substrates

A method for acylating peptides and proteins with the CoA-ester of diheteroatom substituted C.sub.13 to C.sub.14 myristic acid analogs catalyzed by N-myristoyltransferase is presented. In the analogs, two non-adjacent methylene groups, which are normally at positions 3-13, are replaced with oxygen or sulfur atoms.

Method of N-acylating peptide and proteins with diheteroatom substituted

Novel diheteroatom-substituted fatty acid analog substrates of myristoylating enzymes are provided which contain oxyen and/or sulfur in place of two methylene groups in carbon positions from 3 to 13 in the fatty acid chain of a C.sub.13 -C.sub.14 fatty acid analog or alkyl ester thereof in which said oxygen or sulfur atoms are separated by at least one methylene group.

Novel fatty acid analog enzyme substrates

A method of inhibiting viruses by treatment with oxy- and thio-substituted fatty acid analog substrates of myristoylating enzymes is disclosed. These fatty acid analogs contain an oxygen or sulfur in place of a methylene group in a carbon position from 4 to 13 in the fatty acid chain of a C.sub.13 -C.sub.14 fatty acid or alkyl ester thereof.

Growing community of inventors

St. Louis, MO, United States of America

Robert O Heuckeroth