The United States of America, As Represented by the Secretary, Department of Health and Human Services

Enzo Biochem, Inc.

University of Bristol

Robert Nussenblatt

Elazar S Rabbani

James J Donegan

Karl G Csaky

Chi-Chao Chan

Baoying Liu

Lai Wei

Michael R Robinson

Janine A Smith

Peng Yuan

Cynthia Sung

Igal Gery

Matthew P Fronheiser

Hyuncheol Kim

Richard Lee

Dick Andrew

The invention provides immunomodulatory pharmaceutical compositions that include a synthetic peptide and transforming growth factor beta, (TGF-&#x3b2;).

Immunomodulatory pharmaceutical compositions including a synthetic peptide and transforming growth factor beta

The invention provides immunomodulatory pharmaceutical compositions that include a synthetic peptide and one or more immune tolerance enhancers.

Immunomodulatory pharmaceutical compositions

Ocular implant devices () for the delivery of a therapeutic agent to an eye () in a controlled and sustained manner. Dual mode and single mode drug delivery devices () are illustrated and described. Implants () suitable for subconjunctival placement are described. Implants () suitable for intravitreal placement also are described. The invention also includes fabrication and implementation techniques associated with the unique ocular implant devices () that are presented herein.

Ocular therapeutic agent delivery devices and methods for making and using such devices

Ocular implant devices for the delivery of a therapeutic agent to an eye in a controlled and sustained manner. Dual mode and single mode drug delivery devices are illustrated and described. Implants suitable for subconjunctival placement are described. Implants suitable for intravitreal placement also are described. The invention also includes fabrication and implementation techniques associated with the unique ocular implant devices that are presented herein.

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Bethesda, MD, United States of America

Robert Nussenblatt