Other

Amylin Pharmaceuticals, Inc.

Astrazeneca Pharmaceuticals LP

Robert N Jennings

John J Murray

Scott H Coleman

John Ong

Hong Qi

Robin Lee

Gregg Stetsko

Donald Herbert Hartleben

Mary L Houchin

Greg Oehrtman

Robin H Lee

John T H Ong

The disclosure provides one-component, injectable, sustained release formulations which comprise microspheres containing active pharmaceutical ingredients (e.g., exenatide), wherein the microspheres are suspended in a non-aqueous carrier. The non-aqueous carrier can be an oil, a fractionated oil, triglycerides, diglycerides, monoglycerides, propylene glycol fatty acid diesters, and the like. The formulations offer distinct advantages of long shelf life for the stability and potency of the formulation and sustained release of active pharmaceutical ingredients to reduce the frequency of medication dosing and to increase patient compliance.

Sustained release formulations using non-aqueous carriers

Provided are methods and compositions for enhancing the transmucosal absorption of bioactive peptides and proteins. More particularly, the invention provides compositions for enhancing the transmucosal absorption of bioactive peptides and proteins, such as exendin-4, PYY, PYY, and GLP-1 and their analogs and derivatives, wherein the compositions comprise an absorption enhancing mixture of a cationic polyamino acid and a buffer that is compatible with the polyamino acid. Also provided are methods for enhancing the transmucosal absorption and bioavailability of bioactive peptides and proteins using such compositions.

Methods and compositions for enhanced transmucosal delivery of peptides and proteins

The apparatus includes a lock unit having dual eccentrics that are spring biased toward an opposing planar support flange. The lock unit is mounted so that a selected sidewall of a conventional sliding panel track is squeezed between the eccentrics and the support flange by the force of the spring. Slide stops extend from the support flange into the operative area of the track to prevent horizontal sliding movement of the panel. The apparatus further includes a lift stop which may be used in conjunction with the lock unit to prevent the sliding panel from being lifted clear of the lower track. It comprises a flat spring having a bias toward assuming a U-shaped configuration. The spring legs are spread so that the spring can be inserted into the upper panel track above the panel.

Sliding glass window and door lock apparatus including lock unit with

The device locks the sliding panel against horizontal and vertical movement. The device is secured on one of the upraised walls of the panel track by an eccentric that works in opposition to a support flange. The support flange carries slide stops to prevent the panel from sliding in its track. The vertical movement of the window out of the track is prevented by a lift stop comprising a flat spring secured in the upper track or lift stop elements on the support flange.

Sliding glass window and door lock

Growing community of inventors

San Diego, CA, United States of America

Robert N Jennings