Methylation Sciences International Srl

Other

Robert Miller

I David MacDonald

Aniko Takacs-Cox

Nancy Harrison

Compositions and methods to improve the pharmacokinetic profile of S-Adenosylmethionine (SAMe) are provided, as are methods of treating various disorders using SAMe formulations with improved pharmacokinetic profiles. More specifically, the invention is directed to methods of treating a disease or disorder in a subject and/or improving the nutritional status of a subject by administering formulations exhibiting improved pharmacokinetic profiles of exogenous SAMe. The method also includes the step of orally administering compositions of the invention to the subject once per day after overnight fast; that is prior to food intake in the morning.

Pharmacokinetics of S-adenosylmethionine formulations

A drill bit matrix is provided that contains a powdered abrasive material and a refractory metal powder in which the refractory metal powder is a coated powder in which each granule of the refractory metal powder is coated by a coating material. A core drill bit is further provided, containing a powdered abrasive material, a refractory metal powder and a steel tube onto which the powdered abrasive material and refractory metal powder are alloyed. The refractory metal powder is a coated powder in which each granule of the refractory metal powder is coated by one or more coating materials. A method is finally provided for manufacturing a core drill bit. First a matrix is formed by mixing together a powdered abrasive material and a coated refractory metal powder. The matrix is placed in a mould and a steel tube is placed on top of the mould to form a drill bit assembly. The drill bit assembly is then heated under atmospheric conditions. The steel tube is then hot pressed into the heated matrix and the drill bit assembly is allowed to cool before releasing the cooled drill bit from the mould.

Drill bit alloy

An irrigation controller for selectively turning on and off a set of sprinkler valve stations. The irrigation controller is programmable by a user. The irrigation controller includes an irrigation control processor. The irrigation control processor includes an input port, an output port, a memory element for storing an irrigation control program and irrigation control parameters, the irrigation control program implementing a plurality of functionalities that are selectively enabled, a processing unit for executing the irrigation control program, and a bus connecting said processing unit to said memory element and to said input and output ports. An input device is interfaced with the input port. The output port is provided with interface with the sprinkler valve stations for controlling the turning on and off of the sprinkler valve stations. The input device cooperates with the control program to enable at least one specific functionality from the functionalities in response to a predetermined input being received from the user through the input device.

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Delta, Canada

Robert Miller