Qtl Biosystems, LLC

Itt Manufacturing Enterprises, Inc.

Robert Michael Jones

David G Whitten

Duncan W McBranch

Thomas Herman Chyba

Wayne Armstrong

Frauke Rininsland

Steven Andrew MacDonald

Robert Battis

Liangde Lu

Kevin Ley

Stewart McKechnie

Wensheng Xia

Troy S Bergstedt

Sriram Kumaraswamy

Systems and methods for performing Raman spectrometry wherein a Raman spectroscopy system is mounted on a vehicle for on the move contaminant analysis. The system is configured to interrogate a target with a laser at a predetermined pulse repetition frequency (PRF), wherein during each PRF cycle, defined as 1/PRF, the laser is dual pulsed at a first wavelength and at a second wavelength. Raman spectra are collected and used to identify the target by matching a Raman signature with a given collected Raman spectra.

Dual pulse single event Raman spectroscopy

A chemical composition including a fluorescent polymer and a receptor that is specific for both a target biological agent and a chemical moiety including (a) a recognition element, (b) a tethering element, and (c) a property-altering element is disclosed. Both the fluorescent polymer and the receptor are co-located on a support. When the chemical moiety is bound to the receptor, the property-altering element is sufficiently close to the fluorescent polymer to alter the fluorescence emitted by the polymer. When an analyte sample is introduced, the target biological agent, if present, binds to the receptor, thereby displacing the chemical moiety from the receptor, resulting in an increase of detected fluorescence. Assays for detecting the presence of a target biological agent are also disclosed.

Fluorescent polymer superquenching-based bioassays

A chemical composition including a moiety comprising a quencher (Q), a tethering element (T), and a ligand (L) that associates with and quenches a fluorescent polymer is disclosed. When an analyte sample is introduced, the ligand (L) binds to a target biological agent if it is present, thereby causing the QTL molecule to separate from the fluorescent polymer resulting in an increase in detected fluorescence. The same chemistry is advantageously employed in a competitive assay. An electric field can also be applied to separate the QTL molecule from the fluorescent polymer. A method for detecting targets for these methods are also disclosed.

Fluorescent polymer-QTL approach to biosensing

Growing community of inventors

Albuquerque, NM, United States of America

Robert Michael Jones