National Technology & Engineering Solutions of Sandia, LLC

Northwestern University

Sandia Corporation

University of Ottawa

Robert Meagher

Cameron Scott Ball

Ronald Francis Renzi

Annelise E Barron

Chung-Yan Koh

Yooli Kim Light

Kamlesh D Patel

Thomas D Perroud

Phillip Byron Messersmith

Bryan Carson

Wyatt N Vreeland

Andrea R Statz

Gary W Slater

Tyler Phillips Eckles

Stanley Alan Langevin

Aashish Priye

Jonathan Ivers Helm

Laurette C McCormick

Andrea Statz

The present invention relates to methods of conducting cholinesterase inhibition assays. In one instance, the assays can be configured to determine the presence of inactivated and activated cholinesterases. Also described herein are microfluidic devices and systems for conducting such assays.

Detection of cholinesterase inhibition with microfluidic devices and systems thereof

The present invention relates to probes and primers beneficial for conducting amplification assays, such as those including loop-mediated isothermal amplification reactions. Also described herein are methods for detecting targets using such probes and/or primers.

Endpoint detection of amplified nucleic acids

The present invention relates, in part, to systems configured to obtain samples from an organism in an autonomous manner. Such systems can employ a cartridge configured to provide bait to attract an organism, as well as channels to store and/or test samples obtained from the organism.

Real time autonomous surveillance of pathogens

The present invention relates to microfluidic check valves, as well as fluidic cartridges including such check valves. In particular examples, the check valve includes a pre-stressed spring formed from a planar substrate. Various characteristics of the valves, such as size, profile, opening pressure, etc., can be tuned to provide desired performance when employed within a fluidic cartridge.

Check valves for microfluidic systems and methods thereof

Disclosed herein are methods of making micropores of a desired height and/or width between two isotropic wet etched features in a substrate which comprises single-level isotropic wet etching the two features using an etchant and a mask distance that is less than 2&#xd7; a set etch depth. Also disclosed herein are methods using the micropores and microfluidic devices comprising the micropores.

Micropores and methods of making and using thereof

The present invention provides compositions and methods for performing free-solution conjugate analysis of nucleic acid molecules. For example, the present invention provides multiplexed single-base extension assays for genotyping. In particular, the present invention provides a series of disperse polyamide 'drag tags' for use in achieving high-resolution separation of nucleic acid reaction products.

Compositions and methods for free-solution conjugate nucleic acid analysis

Peptidomimetic polymers comprising one or more DOPA moieties and related coatings and composites.

Peptidomimetic polymers for antifouling surfaces

Recently two techniques using free solution electrophoresis to separate charged-uncharged polymer conjugates have proven successful: End Labeled Free Solution Electrophoresis (ELFSE) for DNA sequencing, and Free Solution Conjugate Electrophoresis (FSCE) for molar mass profiling of uncharged polymers. Previous attempts have been made to analyze experimental data generated by these new techniques for the electrophoresis of molecules with varying charge distributions. However, the importance of the ends of the polymers in determining the polymer's overall mobility was neglected in previous work. Through a careful investigation and a reanalysis of the experimental data, it is determined here that this 'end effect' critically impacts the behavior of polymers and charged-uncharged polymer conjugates during electrophoresis. In this way, the invention provides for methods that exploit this 'end effect' for the separation of polymeric molecules on the basis of size, including for example DNA separation and sequencing techniques.

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Mountain House, CA, United States of America

Robert Meagher